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广义核协方差度量AI 解读

We consider the problem of conditional independence (CI) testing and adopt a kernel-based approach. Kernel-based CI tests embed variables in reproducing kernel Hilbert spaces, regress their embeddings on the conditioning variables, and test the resulting residuals for marginal independence. This approach yields tests that are sensitive to a broad range of conditional dependencies. Existing methods, however, rely heavily on kernel ridge regression, which is computationally…

因果中介效应的界AI 解读

Several frameworks have been proposed for studying causal mediation analysis. What these frameworks have in common is that they all make assumptions for point identifications that can be violated even when treatment is randomized. When a causal effect is not point-identified, one can sometimes derive bounds, i.e. a range of possible values that are consistent with the observed data. In this work, we study causal bounds for mediation effects under both the natural effects…

含潜变量的单一或重叠数据集中的分层背景知识与约束式因果发现AI 解读

In this paper we consider the use of tiered background knowledge within constraint based causal discovery. Our focus is on settings relaxing causal sufficiency, i.e. allowing for latent variables which may arise because relevant information could not be measured at all, or not jointly, as in the case of multiple overlapping datasets. We first present novel insights into the properties of the 'tiered FCI' (tFCI) algorithm. Building on this, we introduce a new extension of the…

风险评估的风险：用预测模型作治疗决策时的因果盲点AI 解读

Clinicians increasingly rely on prediction models to guide treatment choices. Most prediction models, however, are developed using observational data that include some patients who have already received the treatment the prediction model is meant to inform. Special attention to the causal role of those earlier treatments is required when interpreting the resulting predictions. We identify 'causal blind spots' in three common approaches to handling treatment when developing a…

利用时间结构改善因果发现的有限样本表现AI 解读

Methods of causal discovery aim to identify causal structures in a data driven way. Existing algorithms are known to be unstable and sensitive to statistical errors, and are therefore rarely used with biomedical or epidemiological data. We present an algorithm that efficiently exploits temporal structure, so-called tiered background knowledge, for estimating causal structures. Tiered background knowledge is readily available from, e.g., cohort or registry data. When used…

连续时间生存与事件史分析中边际因果效应识别的图准则AI 解读

We consider continuous-time survival or more general event-history settings, where the aim is to infer the causal effect of a time-dependent treatment process. This is formalised as the effect on the outcome event of a (possibly hypothetical) intervention on the intensity of the treatment process, i.e. a stochastic intervention. To establish whether valid inference about the interventional situation can be drawn from typical observational, i.e. non-experimental, data we…

基于风险的决策：干预下序贯预测的估计目标AI 解读

Prediction models are used amongst others to inform medical decisions on interventions. Typically, individuals with high risks of adverse outcomes are advised to undergo an intervention while those at low risk are advised to refrain from it. Standard prediction models do not always provide risks that are relevant to inform such decisions: e.g., an individual may be estimated to be at low risk because similar individuals in the past received an intervention which lowered…

因果模型的参数化与模拟AI 解读

Many statistical problems in causal inference involve a probability distribution other than the one from which data are actually observed; as an additional complication, the object of interest is often a marginal quantity of this other probability distribution. This creates many practical complications for statistical inference, even where the problem is non-parametrically identified. In particular, it is difficult to perform likelihood-based inference, or even to simulate…

不完整队列数据因果发现中的多重插补与逐检验删除AI 解读

Causal discovery algorithms estimate causal graphs from observational data. This can provide a valuable complement to analyses focussing on the causal relation between individual treatment-outcome pairs. Constraint-based causal discovery algorithms rely on conditional independence testing when building the graph. Until recently, these algorithms have been unable to handle missing values. In this paper, we investigate two alternative solutions: Test-wise deletion and multiple…