Parametric G-computation for Compatible Indirect Treatment Comparisons with Limited Individual Patient Data
个体患者数据有限时相容间接治疗比较的参数化 G 计算
Population adjustment methods such as matching-adjusted indirect comparison (MAIC) are increasingly used to compare marginal treatment effects when there are cross-trial differences in effect modifiers and limited patient-level data. MAIC is based on propensity score weighting, which is sensitive to poor covariate overlap and cannot extrapolate beyond the observed covariate space. Current outcome regression-based alternatives can extrapolate but target a conditional…