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Discovery and Inference of a Causal Network with Hidden Confounding

存在隐蔽混杂的因果网络发现与推断

This article proposes a novel causal discovery and inference method called GrIVET for a Gaussian directed acyclic graph with unmeasured confounders. GrIVET consists of an order-based causal discovery method and a likelihood-based inferential procedure. For causal discovery, we generalize the existing peeling algorithm to estimate the ancestral relations and candidate instruments in the presence of hidden confounders. Based on this, we propose a new procedure for instrumental…

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Nonlinear Causal Discovery with Confounders

存在混杂时的非线性因果发现

This article introduces a causal discovery method to learn nonlinear relationships in a directed acyclic graph with correlated Gaussian errors due to confounding. First, we derive model identifiability under the sublinear growth assumption. Then, we propose a novel method, named the Deconfounded Functional Structure Estimation (DeFuSE), consisting of a deconfounding adjustment to remove the confounding effects and a sequential procedure to estimate the causal order of…

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Distribution-invariant differential privacy

分布不变的差分隐私

Differential privacy is becoming one gold standard for protecting the privacy of publicly shared data. It has been widely used in social science, data science, public health, information technology, and the U.S. decennial census. Nevertheless, to guarantee differential privacy, existing methods may unavoidably alter the conclusion of original data analysis, as privatization often changes the sample distribution. This phenomenon is known as the trade-off between privacy…

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Causal Inference in Transcriptome-Wide Association Studies with Invalid Instruments and GWAS Summary Data

无效工具变量与 GWAS 汇总数据下的转录组关联研究因果推断

Transcriptome-wide association studies (TWAS) have recently emerged as a popular tool to discover (putative) causal genes by integrating an outcome GWAS dataset with another gene expression/transcriptome GWAS (called eQTL) dataset. In our motivating and target application, we'd like to identify causal genes for low-density lipoprotein cholesterol (LDL), which is crucial for developing new treatments for hyperlipidemia and cardiovascular diseases. The statistical principle…

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Collaborative Multilabel Classification

协作式多标签分类

In multilabel classification, strong label dependence is present for exploiting, particularly for word-to-word dependence defined by semantic labels. In such a situation, we develop a collaborative-learning framework to predict class labels based on label-predictor pairs and label-only data. For example, in image categorization and recognition, language expressions describe the content of an image together with a large number of words and phrases without associated images.…

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Coupled Generation

耦合生成:结合直接与间接生成器的实例生成方法

Instance generation creates representative examples to interpret a learning model, as in regression and classification. For example, representative sentences of a topic of interest describe the topic specifically for sentence categorization. In such a situation, a large number of unlabeled observations may be available in addition to labeled data, for example, many unclassified text corpora (unlabeled instances) are available with only a few classified sentences (labeled…

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Embedding Learning

嵌入学习

Numerical embedding has become one standard technique for processing and analyzing unstructured data that cannot be expressed in a predefined fashion. It stores the main characteristics of data by mapping it onto a numerical vector. An embedding is often unsupervised and constructed by transfer learning from large-scale unannotated data. Given an embedding, a downstream learning method, referred to as a two-stage method, is applicable to unstructured data. In this article,…

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Scalable Collaborative Ranking for Personalized Prediction

面向个性化预测的可扩展协同排序

Ben Daiab, Xiaotong Shena, Junhui Wangb & Annie Quc* a School of Statistics, University of Minnesota , Minneapolis , MN ; b School of Data Science, City University of Hong Kong , Kowloon Tong, Hong Kong ; c Department of Statistics, University of Illinois at Urbana Champaign , Champaign , IL Supplementary materials for this article are available online. Please go to www.tandfonline.com/r/JASA. CONTACT Annie Qu anniequ@illinois.edu Department of Statistics, University of…

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Likelihood Ratio Tests for a Large Directed Acyclic Graph

大型有向无环图的似然比检验

Inference of directional pairwise relations between interacting units in a directed acyclic graph (DAG), such as a regulatory gene network, is common in practice, imposing challenges because of lack of inferential tools. For example, inferring a specific gene pathway of a regulatory gene network is biologically important. Yet, frequentist inference of directionality of connections remains largely unexplored for regulatory models. In this article, we propose constrained…

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Discussion of “From Fixed-X to Random-X Regression: Bias-Variance Decompositions, Covariance Penalties, and Prediction Error Estimation”

《从固定 X 到随机 X 回归:偏差方差分解、协方差惩罚与预测误差估计》讨论

Rosset and Tibshirani are to be congratulated for addressing an important yet under-studied topic of modern statistics, so-called Random-X prediction in regression analysis. In statistics, Random-X...

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On High-Dimensional Constrained Maximum Likelihood Inference

高维约束最大似然推断

Inference in a high-dimensional situation may involve regularization of a certain form to treat overparameterization, imposing challenges to inference. The common practice of inference uses either a regularized model, as in inference after model selection, or bias-reduction known as “debias.” While the first ignores statistical uncertainty inherent in regularization, the second reduces the bias inbred in regularization at the expense of increased variance. In this article,…

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Constrained likelihood for reconstructing a directed acyclic Gaussian graph

通过约束似然重建高斯有向无环图

Directed acyclic graphs are widely used to describe directional pairwise relations. Such relations are estimated by reconstructing a directed acyclic graph's structure, which is challenging when the ordering of nodes of the graph is unknown. In such a situation, existing methods such as the neighbourhood and search-and-score methods have high estimation errors or computational complexities, especially when a local or sequential approach is used to enumerate edge directions…

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Multilayer tensor factorization with applications to recommender systems

多层张量分解及其在推荐系统中的应用

Recommender systems have been widely adopted by electronic commerce and entertainment industries for individualized prediction and recommendation, which benefit consumers and improve business intelligence. In this article, we propose an innovative method, namely the recommendation engine of multilayers (REM), for tensor recommender systems. The proposed method utilizes the structure of a tensor response to integrate information from multiple modes, and creates an additional…

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A Group-Specific Recommender System

群组特定的推荐系统

In recent years, there has been a growing demand to develop efficient recommender systems which track users’ preferences and recommend potential items of interest to users. In this article, we propose a group-specific method to use dependency information from users and items which share similar characteristics under the singular value decomposition framework. The new approach is effective for the “cold-start” problem, where, in the testing set, majority responses are…

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Personalized Prediction and Sparsity Pursuit in Latent Factor Models

潜在因子模型中的个性化预测与稀疏性追求

Yunzhang Zhu, Xiaotong Shen & Changqing YeYunzhang Zhu (E-mail: zhuxx351@umn.edu), Xiaotong Shen (E-mail: shenx002@umn.edu), and Changqing Ye (E-mail: cqye@stat.umn.edu), School of Statistics, University of Minnesota, Minneapolis, MN 55455. Research supported in part by NSF grants DMS-1207771 and DMS-1415500, NIH grants R02GM08153 and R01HL105397. The authors would like to thank Professor Hui Jiang for technical help in OpenMP coding, and thank the editor, the associate…

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Adaptive Modeling Procedure Selection by Data Perturbation

基于数据扰动的自适应建模程序选择

Many procedures have been developed to deal with the high-dimensional problem that is emerging in various business and economics areas. To evaluate and compare these procedures, modeling uncertainty caused by model selection and parameter estimation has to be assessed and integrated into a modeling process. To do this, a data perturbation method estimates the modeling uncertainty inherited in a selection process by perturbing the data. Critical to data perturbation is the…

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Structural Pursuit Over Multiple Undirected Graphs

多个无向图的结构追寻

Gaussian graphical models are useful to analyze and visualize conditional dependence relationships between interacting units. Motivated from network analysis under different experimental conditions, such as gene networks for disparate cancer subtypes, we model structural changes over multiple networks with possible heterogeneities. In particular, we estimate multiple precision matrices describing dependencies among interacting units through maximum penalized likelihood. Of…

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Simultaneous Grouping Pursuit and Feature Selection Over an Undirected Graph

无向图上的同步分组搜索与特征选择

In high-dimensional regression, grouping pursuit and feature selection have their own merits while complementing each other in battling the curse of dimensionality. To seek a parsimonious model, we perform simultaneous grouping pursuit and feature selection over an arbitrary undirected graph with each node corresponding to one predictor. When the corresponding nodes are reachable from each other over the graph, regression coefficients can be grouped, whose absolute values…

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Likelihood-Based Selection and Sharp Parameter Estimation

基于似然的变量选择与精确参数估计

In high-dimensional data analysis, feature selection becomes one means for dimension reduction, which proceeds with parameter estimation. Concerning accuracy of selection and estimation, we study nonconvex constrained and regularized likelihoods in the presence of nuisance parameters. Theoretically, we show that constrained L(0)-likelihood and its computational surrogate are optimal in that they achieve feature selection consistency and sharp parameter estimation, under one…

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Grouping Pursuit Through a Regularization Solution Surface

通过正则化解曲面追寻预测变量分组

Extracting grouping structure or identifying homogenous subgroups of predictors in regression is crucial for high-dimensional data analysis. A low-dimensional structure in particular-grouping, when captured in a regression model, enables to enhance predictive performance and to facilitate a model's interpretability Grouping pursuit extracts homogenous subgroups of predictors most responsible for outcomes of a response. This is the case in gene network analysis, where…

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On L 1 -Norm Multiclass Support Vector Machines

L1范数多分类支持向量机

Binary support vector machines (SVMs) have been proven to deliver high performance. In multiclass classification, however, issues remain with respect to variable selection. One challenging issue is classification and variable selection in the presence of variables in the magnitude of thousands, greatly exceeding the size of training sample. This often occurs in genomics classification. To meet the challenge, this article proposes a novel multiclass support vector machine,…

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Discussion: Local Rademacher complexities and oracle inequalities in risk minimization

讨论:风险最小化中的局部Rademacher复杂度与预言机不等式

Koltchinskii is to be congratulated for developing a unified framework.This elegant framework is general and allows a user to apply it directly instead of deriving bounds in each risk minimization problem.In the past decade, the problem of risk minimization has been extensively studied in function estimation and classification.In function estimation, it has been investigated using the empirical process technique under the name of minimum contrast or sieve estimation in, for…

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Multicategory ψ -Learning

多类别 ψ 学习

In binary classification, margin-based techniques usually deliver high performance. As a result, a multicategory problem is often treated as a sequence of binary classifications. In the absence of a dominating class, this treatment may be suboptimal and may yield poor performance, such as for support vector machines (SVMs). We propose a novel multicategory generalization of ψ-learning that treats all classes simultaneously. The new generalization eliminates this potential…

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Inference After Model Selection

模型选择后的统计推断

Typical modeling strategies involve model selection, which has a significant effect on inference of estimated parameters. Common practice is to use a selected model ignoring uncertainty introduced by the process of model selection. This could yield overoptimistic inferences, resulting in false discovery. In this article we develop a general methodology via optimal approximation for estimating the mean and variance of complex statistics that involve the process of model…

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