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Biased Encouragements and Heterogeneous Effects in an Instrumental Variable Study of Emergency General Surgical Outcomes

急诊普外科结局工具变量研究中的偏倚鼓励与异质性效应

We investigate the efficacy of surgical versus nonsurgical management for two gastrointestinal conditions, colitis and diverticulitis, using observational data. We deploy an instrumental variable design with surgeons’ tendencies to operate as an instrument. Assuming instrument validity, we find that nonsurgical alternatives can reduce both hospital length of stay and the risk of complications, with estimated effects larger for septic patients than for nonseptic patients. The…

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Discovering Heterogeneous Exposure Effects Using Randomization Inference in Air Pollution Studies

利用随机化推断发现空气污染暴露效应的异质性

Several studies have provided strong evidence that long-term exposure to air pollution, even at low levels, increases risk of mortality. As regulatory actions are becoming prohibitively expensive, robust evidence to guide the development of targeted interventions to protect the most vulnerable is needed. In this article, we introduce a novel statistical method that (i) discovers subgroups whose effects substantially differ from the population mean, and (ii) uses…

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Estimating the Malaria Attributable Fever Fraction Accounting for Parasites Being Killed by Fever and Measurement Error

考虑发热杀灭寄生虫与测量误差的疟疾归因发热比例估计

Malaria is a major health problem in many tropical regions. Fever is a characteristic symptom of malaria. The fraction of fevers that are attributable to malaria, the malaria attributable fever fraction (MAFF), is an important public health measure in that the MAFF can be used to calculate the number of fevers that would be avoided if malaria was eliminated. Despite such causal interpretation, the MAFF has not been considered in the framework of causal inference. We define…

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