论文检索

遗传风险评分构建：投影汇总统计与灵活收缩的稳健贝叶斯方法AI 解读

Polygenic risk scores (PRS) developed from genome-wide association studies (GWAS) can be used for risk stratification by quantifying the genetic contribution to disease, and many clinical applications have been proposed. Bayesian methods are popular for building PRS because of their natural ability to regularize models and incorporate external information. In this article, we present new theoretical results, methods, and extensive numerical studies to advance Bayesian…

连接两类蒙特卡洛采样器的折线路径：分段确定性马尔可夫过程的哈密顿对应AI 解读

Zigzag and other piecewise deterministic Markov process samplers have attracted significant interest for their non-reversibility and other appealing properties for Bayesian posterior computation. Hamiltonian Monte Carlo is another state-of-the-art sampler, exploiting fictitious momentum to guide Markov chains through complex target distributions. We establish an important connection between the zigzag sampler and a variant of Hamiltonian Monte Carlo based on…

以先验预条件共轭梯度法加速大样本高维贝叶斯稀疏回归的 Gibbs 抽样AI 解读

In a modern observational study based on healthcare databases, the number of observations and of predictors typically range in the order of 10^{5}-10^{6} and of 10^{4}-10^{5}. Despite the large sample size, data rarely provide sufficient information to reliably estimate such a large number of parameters. Sparse regression techniques provide potential solutions, one notable approach being the Bayesian method based on shrinkage priors. In the "large n and large p" setting,…

用于离散参数与不连续似然的非连续哈密顿蒙特卡洛AI 解读

Summary Hamiltonian Monte Carlo has emerged as a standard tool for posterior computation. In this article we present an extension that can efficiently explore target distributions with discontinuous densities. Our extension in particular enables efficient sampling from ordinal parameters through the embedding of probability mass functions into continuous spaces. We motivate our approach through a theory of discontinuous Hamiltonian dynamics and develop a corresponding…

贝叶斯约束松弛AI 解读

Summary Prior information often takes the form of parameter constraints. Bayesian methods include such information through prior distributions having constrained support. By using posterior sampling algorithms, one can quantify uncertainty without relying on asymptotic approximations. However, sharply constrained priors are not necessary in some settings and tend to limit modelling scope to a narrow set of distributions that are tractable computationally. We propose to…