每日简报

关联研究中的函数型方差分析AI 解读

While progress has been made in identifying common genetic variants associated with human diseases, for most of common complex diseases, the identified genetic variants only account for a small proportion of heritability. Challenges remain in finding additional unknown genetic variants predisposing to complex diseases. With the advance in next-generation sequencing technologies, sequencing studies have become commonplace in genetic research. The ongoing exome-sequencing and…

用偏相关图LASSO识别网络枢纽AI 解读

Graphical LASSO (GLASSO) is a widely used method for estimating sparse precision matrices and learning undirected graphical models in high-dimensional settings. Because GLASSO penalizes entries of the precision matrix directly, however, it is not scale-invariant. Partial Correlation Graphical LASSO (PCGLASSO), introduced by Carter et al. (2024), addresses this limitation by penalizing partial correlations, which directly characterize conditional dependence. In this paper, we…

结合实验与观察数据对分布处理效应参数的识别能力AI 解读

This study investigates whether and how combining experimental data, in which treatment is randomized, with observational data, in which treatment is self-selected, improves identification of distributional treatment effect (DTE) parameters. Many DTE parameters remain partially identified even under randomized treatment assignment. We show that the combined data reveal how potential-outcome distributions vary across latent self-selection types and that this information fully…

模型不确定性的综述与分类AI 解读

Model uncertainty is a crucial issue in statistics, econometrics and machine learning, yet its definition remains ambiguous and is subject to various interpretations in the literature. So far, there has not been a universally accepted definition of model uncertainty. We review different understandings of model uncertainty and categorize them into three distinct types: uncertainty about the true model, model selection uncertainty, and model selection instability. We further…

单调连续处理效应曲线的双重稳健逐点置信区间AI 解读

We study nonparametric inference for the causal dose-response (or treatment effect) curve when the treatment variable is continuous rather than binary or discrete. We do this by developing doubly robust confidence intervals for the continuous treatment effect curve (at a fixed point) under the assumption that it is monotonic, based on inverting a likelihood ratio-type test. Monotonicity of the treatment effect curve is often a very natural assumption, and this assumption…

异质时空 GARCH：金融网络波动率预测框架AI 解读

We introduce a heterogeneous spatiotemporal GARCH model for geostatistical data or processes on networks, e.g., for modelling and predicting financial return volatility across firms in a latent spatial framework. The model combines classical GARCH(p, q) dynamics with spatially correlated innovations and spatially varying parameters, estimated using local likelihood methods. Spatial dependence is introduced through a geostatistical covariance structure on the innovation…

基于 Copula 标准化流的未观测混杂敏感性分析AI 解读

We propose a novel method for sensitivity analysis to unobserved confounding in causal inference. The method builds on a copula-based causal graphical normalizing flow that we term $ρ$-GNF, where $ρ\in [-1,+1]$ is the sensitivity parameter. The parameter represents the non-causal association between exposure and outcome due to unobserved confounding, which is modeled as a Gaussian copula. In other words, the $ρ$-GNF enables scholars to estimate the average causal effect…

观点：因果机器学习的广泛应用需要严格的合成实验AI 解读

Causal machine learning has the potential to revolutionize decision-making by combining the predictive power of machine learning algorithms with the theory of causal inference. However, these methods remain underutilized by the broader machine learning community, in part because current empirical evaluations do not permit assessment of their reliability and robustness, undermining their practical utility. Specifically, one of the principal criticisms made by the community is…

近似稀疏函数类与极小极大估计AI 解读

Motivated by the orthogonal series density estimation in $L^2([0,1],μ)$, in this project we consider a new class of functions that we call the approximate sparsity class. This new class is characterized by the rate of decay of the individual Fourier coefficients for a given orthonormal basis. We establish the $L^2([0,1],μ)$ metric entropy of such class, with which we show the minimax rate of convergence. For the density subset in this class, we propose an adaptive density…

序贯自适应实验的有效统计估计及其对自适应设计的启示AI 解读

Adaptive experimental designs have gained popularity in clinical trials and online experiments. Unlike traditional, fixed experimental designs, adaptive designs can dynamically adjust treatment randomization probabilities and other design features in response to data accumulated sequentially during the experiment. These adaptations are useful to achieve diverse objectives, including reducing uncertainty in the estimation of causal estimands or increasing participants'…

用 LIME 与 SHAP 解释时间序列预测：航空旅客数据案例AI 解读

Time-series forecasting underpins critical decisions across aviation, energy, retail and health. Classical autoregressive integrated moving average (ARIMA) models offer interpretability via coefficients but struggle with nonlinearities, whereas tree-based machine-learning models such as XGBoost deliver high accuracy but are often opaque. This paper presents a unified framework for interpreting time-series forecasts using local interpretable model-agnostic explanations (LIME)…

工具变量回归中弱工具稳健推断的统计学指南及 Python 示例AI 解读

We provide an overview of results relating to estimation and weak-instrument-robust inference in instrumental variables regression. Methods are implemented in the ivmodels software package for Python, which we use to illustrate results.

加权平均处理效应的方差估计AI 解读

Common variance estimation methods for weighted average treatment effects (WATEs) in observational studies include nonparametric bootstrap and model-based, closed-form sandwich variance estimation. However, the computational cost of bootstrap increases with the size of the data at hand. Besides, some replicates may exhibit random violations of the positivity assumption even when the original data do not. Sandwich variance estimation relies on regularity conditions that may…

含随机效应的混合分数 Black–Scholes 模型：离散观测下的混合估计AI 解读

We propose a hybrid estimation procedure to estimate global fixed parameters and subject-specific random effects in a mixed fractional Black-Scholes model based on discrete-time observations. Specifically, we consider $N$ independent stochastic processes, each driven by a linear combination of standard Brownian motion and an independent fractional Brownian motion, and governed by a drift term that depends on an unobserved random effect with unknown distribution. Based on $n$…

利用时间层级预测提高日前电价预测精度：THieFAI 解读

We introduce the concept of temporal hierarchy forecasting (THieF) in predicting day-ahead electricity prices and show that reconciling forecasts for hourly products and 2- to 24-hour blocks can significantly (up to 13%) improve accuracy at all levels. These results remain consistent throughout a challenging 4-year test period (2021-2024) in the German and Spanish power markets and across model architectures, including linear regression, shallow feedforward neural networks,…

高维矩阵时间序列主效应因子模型的识别与稀疏性AI 解读

We propose a general identification framework for main effect factor models for matrix-valued time series. The classical sum-to-zero restriction on the row and column main effects is replaced by a broad class of shift-varying functions, which includes weighted averages, quantiles, and reference-unit anchors as special cases. We prove that the shift-varying property is necessary and sufficient for parameter identification, and we derive closed-form estimators under minimal…

因果测地学：沿相关与因果之间的路径估计反事实AI 解读

We introduce causal geodesy, a framework for studying the landscape of stochastic interventions that lie between the two extremes of performing no intervention and performing a sharp intervention that sets an exposure equal to a specific value. We define this framework by constructing paths of distributions that smoothly interpolate between the treatment density and a point mass at the target intervention. Thus, each path starts at a purely observational (or correlational)…

未观测混杂的多元回归分析AI 解读

Whereas confidence intervals are used to assess uncertainty due to unmeasured individuals, confounding intervals can be used to assess uncertainty due to unmeasured attributes. Previously, we have introduced a methodology for computing confounding intervals in a simple regression setting in a paper titled ``Regression Analysis of Unmeasured Confounding." Here we extend that methodology for more general application in the context of multiple regression. Our multiple…

图神经网络的过度压缩与重连策略的因果评估AI 解读

Graph neural networks (GNNs) have exhibited state-of-the-art performance across wide-range of domains such as recommender systems, material design, and drug repurposing. Yet message-passing GNNs suffer from over-squashing -- exponential compression of long-range information from distant nodes -- which limits expressivity. Rewiring techniques can ease this bottleneck; but their practical impacts are unclear due to the lack of a direct empirical over-squashing metric. We…

随机效应模型下多区域临床试验的一致性评估与样本量计算AI 解读

Multi-regional clinical trials (MRCTs) have become common practice for drug development and global registration. Once overall significance is established, demonstrating regional consistency is critical for local health authorities. Methods for evaluating such consistency and calculating regional sample sizes have been proposed based on the fixed effects model using various criteria. To better account for the heterogeneity of treatment effects across regions, the random…

协变量缺失时协变量自适应随机试验的回归调整AI 解读

Covariate-adaptive randomization is widely used in clinical trials to balance prognostic factors, and regression adjustments are often adopted to further enhance the estimation and inference efficiency. In practice, the covariates may contain missing values. Various methods have been proposed to handle the covariate missing problem under simple randomization. However, the statistical properties of the resulting average treatment effect estimators under stratified…

早期临床试验中零膨胀生物标志物的两步检验AI 解读

In early-phase clinical trials, a predictive biomarker may identify subgroups that benefit from an experimental therapy, even when the overall average treatment effect is negligible. Recently proposed nonparametric interaction tests such as the Average Kolmogorov-Smirnov Approach (AKSA) avoid prespecified biomarker cutting points and model assumptions, but their power degrades when the biomarker distribution is zero-inflated. We propose a two-step test that partitions the…

自相关数据下 Mann–Kendall tau 的高斯分布问题AI 解读

Non-parametric Mann-Kendall tests for autocorrelated data rely on the assumption that the distribution of the normalized Mann-Kendall tau is Gaussian. While this assumption holds asymptotically for stationary autoregressive processes of order 1 (AR(1)) and simple moving average (SMA) processes when sampling over an increasingly long period, it often fails for finite-length time series. In such cases, the empirical distribution of the Mann-Kendall tau deviates significantly…

特征与自回归滞后的贝叶斯联合选择：环境与金融预测应用AI 解读

We develop a Bayesian framework for variable selection in linear regression with autocorrelated errors, accommodating lagged covariates and autoregressive structures. This setting occurs in time series applications where responses depend on contemporaneous or past explanatory variables and persistent stochastic shocks, including financial modeling, hydrological forecasting, and meteorological applications requiring temporal dependency capture. Our methodology uses…