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I study inverse probability weighted M-estimation under a general missing data scheme. Examples include M-estimation with missing data due to a censored survival time, propensity score estimation of the average treatment effect in the linear exponential family, and variable probability sampling with observed retention frequencies. I extend an important result known to hold in special cases: estimating the selection probabilities is generally more efficient than if the known selection probabilities could be used in estimation. For the treatment effect case, the setup allows a general characterization of a “double robustness” result due to Scharfstein, Rotnitzky, and Robins (1999).