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In the presence of heteroscedasticity, ordinary least squares (OLS) estimates are unbiased, but the usual tests of significance are generally inappropriate and their use can lead to incorrect inferences. Tests based on a heteroscedasticity consistent covariance matrix (HCCM), however, are consistent even in the presence of heteroscedasticity of an unknown form. Most applications that use a HCCM appear to rely on the asymptotic version known as HC0. Our Monte Carlo simulations show that HC0 often results in incorrect inferences when N ≤ 250, while three relatively unknown, small sample versions of the HCCM, and especially a version known as HC3, work well even for N's as small as 25. We recommend that: (1) data analysts should correct for heteroscedasticity using a HCCM whenever there is reason to suspect heteroscedasticity; (2) the decision to use HCCM-based tests should not be determined by a screening test for heteroscedasticity; and (3) when N ≤ 250, the HCCM known as HC3 should be used. Since HC3 is simple to compute, we encourage authors of statistical software to add this estimator to their programs.