Leveraging Local Distributions in Mendelian Randomization: Uncertain Opinions are Invalid
利用局部分布开展孟德尔随机化:不确定的意见无效
Mendelian randomization (MR) considers using genetic variants as instrumental variables (IVs) to infer causal effects in observational studies. However, the validity of causal inference in MR can be compromised when the IVs are potentially invalid. In this work, we propose a new method, MR-Local, to infer the causal effect in the existence of possibly invalid IVs. By leveraging the distribution of ratio estimates around the true causal effect, MR-Local selects the cluster of…