A Unified Three-State Model Framework for Analysis of Treatment Crossover in Survival Trials
生存试验中治疗交叉分析的统一三状态模型框架
We present a unified three-state model (TSM) framework for evaluating treatment effects in clinical trials in the presence of treatment crossover. Researchers have proposed diverse methodologies to estimate the treatment effect that would have hypothetically been observed if treatment crossover had not occurred. However, there is little work on understanding the connections between these different approaches from a statistical point of view. The proposed TSM framework…