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随机对照试验中风险比的不可折叠性与内生选择偏差AI 解读

Background: The hazard ratio of the Cox proportional hazards model is widely used in randomized controlled trials to assess treatment effects. However, two properties of the hazard ratio including the non-collapsibility and built-in selection bias need to be further investigated. Methods: We conduct simulations to differentiate the non-collapsibility effect and built-in selection bias from the difference between the marginal and the conditional hazard ratio. Meanwhile, we…

用于高维纵向数据聚类的稀疏因子模型AI 解读

Recent advances in engineering technologies have enabled the collection of a large number of longitudinal features. This wealth of information presents unique opportunities for researchers to investigate the complex nature of diseases and uncover underlying disease mechanisms. However, analyzing such kind of data can be difficult due to its high dimensionality, heterogeneity and computational challenges. In this paper, we propose a Bayesian nonparametric mixture model for…