The Effect of Alcohol intake on Brain White Matter Microstructural Integrity: A New Causal Inference Framework for Incomplete Phenomic Data
饮酒对脑白质微结构完整性的影响:不完整表型数据的因果推断框架
Although substance use, such as alcohol intake, is known to be associated with cognitive decline during aging, its direct influence on the central nervous system remains incompletely understood. In this study, we investigate the influence of alcohol intake frequency on reduction of brain white matter microstructural integrity in the fornix, a brain region considered a promising marker of age-related microstructural degeneration, using a large UK Biobank (UKB) cohort with…