Covariate-Adaptive Randomization in Clinical Trials without Inflated Variances
不膨胀协变量不平衡方差的临床试验自适应随机化
Covariate adaptive randomization (CAR) procedures are extensively used to reduce the likelihood of covariate imbalances occurring in clinical trials. In literatures, a lot of CAR procedures have been proposed so that the specified covariates are balanced well between treatments. However, the variance of the imbalance of the unspecified covariates may be inflated comparing to the one under the simple randomization. The inflation of the variance causes the usual test of…