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时变神谕治疗策略的性能界限AI 解读

Much causal inference research is focused on methods for optimizing dynamic treatment regimes (Murphy, 2003; Robins, 2004; Schulte et al., 2015), which are rules for deciding which treatments should be assigned and when based on evolving history. There is a certain optimism underlying this endeavor that with enough tinkering we might realize consequential improvements. Another strand of research, previously confined to the point exposure setting, considers bounds on how well…

平行趋势假设下的结构嵌套均值模型AI 解读

We link and extend two approaches to estimating time-varying treatment effects on repeated continuous outcomes--time-varying Difference in Differences (DiD; see Roth et al. (2023) and Chaisemartin et al. (2023) for reviews) and Structural Nested Mean Models (SNMMs; see Vansteelandt and Joffe (2014) for a review). In particular, we show that SNMMs, previously known to be nonparametrically identified under a no unobserved confounding assumption, are also identified under a…

从单项研究识别与估计潜在结果的联合分布AI 解读

Most causal inference methods focus on estimating marginal average treatment effects, but many important causal estimands depend on the joint distribution of potential outcomes, including the probability of causation and proportions benefiting from or harmed by treatment. Wu et al (2025) recently established nonparametric identification of this joint distribution for categorical outcomes under binary treatment by leveraging variation across multiple studies. We demonstrate…

将双重差分推广至非典型情形：识别多种因果估计对象AI 解读

Consider a general setting in which data on an outcome is collected in two `groups' at two time periods, with certain group-periods deemed `treated' and others `untreated'. A special case is the canonical Difference-in-Differences (DiD) setting in which one group is treated only in the second period while the other is treated in neither period. Then it is well known that under a parallel trends assumption across the two groups the classic DiD formula (subtracting the average…

利用因果图评估双重差分研究的平行趋势AI 解读

Difference-in-differences (DID) is popular because it can allow for unmeasured confounding when the key assumption of parallel trends holds. However, there exists little guidance on how to decide a priori whether this assumption is reasonable. We attempt to develop such guidance by considering the relationship between a causal diagram and the parallel trends assumption. This is challenging because parallel trends is scale-dependent and causal diagrams are generally…

利用反事实删失无偏变换估计生存结局的异质性处理效应AI 解读

Methods for estimating heterogeneous treatment effects (HTE) from observational data have largely focused on continuous or binary outcomes, with less attention paid to survival outcomes and almost none to settings with competing risks. In this work, we develop censoring unbiased transformations (CUTs) for survival outcomes both with and without competing risks. After converting time-to-event outcomes using these CUTs, direct application of HTE learners for continuous…

用双重／去偏机器学习有效估计加权累积治疗效应AI 解读

In empirical studies with time-to-event outcomes, investigators often leverage observational data to conduct causal inference on the effect of exposure when randomized controlled trial data is unavailable. Model misspecification and lack of overlap are common issues in observational studies, and they often lead to inconsistent and inefficient estimators of the average treatment effect. Estimators targeting overlap weighted effects have been proposed to address the challenge…

近端识别假设违反时的偏差公式AI 解读

Causal inference from observational data often rests on the unverifiable assumption of no unmeasured confounding. Recently, Tchetgen Tchetgen and colleagues have introduced proximal inference to leverage negative control outcomes and exposures as proxies to adjust for bias from unmeasured confounding. However, some of the key assumptions that proximal inference relies on are themselves empirically untestable. Additionally, the impact of violations of proximal inference…