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稳定化高阶影响函数：一类双线性形式的统计理论AI 解读

Higher-order influence functions, introduced in a series of articles (Robins et al., 2008, 2009a; van der Vaart, 2014; Robins et al., 2016, 2023; Liu et al., 2017), are a unified framework for constructing rate-optimal point estimates of a class of statistical functionals under various complexity-reducing assumptions on the posited statistical model that generates the observed data. Although higher-order (influence functions) estimators are theoretically appealing, they have…

协变量自适应随机化下 p=o(n) 的弱模型假设协变量调整AI 解读

Adjusting for (baseline) covariates with working regression models becomes standard practice in the analysis of randomized clinical trials (RCT). When the dimension $p$ of the covariates is large relative to the sample size $n$, specifically $p = o (n)$, adjusting for covariates even in a linear working model by ordinary least squares can yield overly large bias, defeating the purpose of improving efficiency. This issue arises when no structural assumptions are imposed on…

利用外部数据分析随机临床试验：迁移学习方法AI 解读

Randomized clinical trials are the gold standard for analyzing treatment effects, but high costs and ethical concerns can limit recruitment, potentially leading to invalid inferences. Incorporating external trial data with similar characteristics into the analysis using transfer learning appears promising for addressing these issues. In this paper, we present a formal framework for applying transfer learning to the analysis of clinical trials, considering three key…