Evaluating causal effects on time-to-event outcomes in an RCT in Oncology with treatment discontinuation
存在治疗中止的肿瘤随机试验中事件时间结局的因果效应评估
In clinical trials, patients may discontinue treatments prematurely, breaking the initial randomization and, thus, challenging inference. Stakeholders in drug development are generally interested in going beyond the Intention-To-Treat (ITT) analysis, which provides valid causal estimates of the effect of treatment assignment but does not inform on the effect of the actual treatment receipt. Our study is motivated by an RCT in oncology, where patients assigned the…