Performance of prior event rate ratio method in the presence of differential mortality or dropout
差异性死亡或退出下既往事件率比方法的表现
Purpose: Prior event rate ratio (PERR) method was proposed to control for measured or unmeasured confounders in real-world evaluation of effectiveness and safety of medical treatments using electronic medical records data. A widely cited simulation study showed that PERR estimate of treatment effect was biased in the presence of differential morality/dropout. However, the study only considered one specific PERR estimator of treatment effect and one specific scenario of…