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协变量约束随机化的整群试验规划：模拟设计与闭式功效计算的乍得农村案例比较AI 解读

Current practices for designing cluster-randomized trials (cRCTs) typically rely on closed-form formulas for power calculations. For cRCTs using covariate-constrained randomization, the utility of conventional calculations might be limited, particularly when data is nested. We compared simulation-based planning of a nested cRCT using covariate-constrained randomization to conventional power calculations using OptiMAx-Chad as a case study. OptiMAx-Chad will examine the impact…

仅利用目标总体汇总数据的可迁移性分析：目标聚合数据调整法AI 解读

Transportability analysis is a causal inference framework used to evaluate the external validity of randomized clinical trials (RCTs) or observational studies. Most existing transportability analysis methods require individual patient-level data (IPD) for both the source and the target population, narrowing its applicability when only target aggregate-level data (AgD) is available. Besides, accounting for censoring is essential to reduce bias in longitudinal data, yet…