Consistent Covariance estimation for stratum imbalances under minimization method for covariate-adaptive randomization
协变量自适应最小化随机分配下分层不平衡协方差的一致估计
Pocock and Simon's minimization method is a popular approach for covariate-adaptive randomization in clinical trials. Valid statistical inference with data collected under the minimization method requires the knowledge of the limiting covariance matrix of within-stratum imbalances, whose existence is only recently established. In this work, we propose a bootstrap-based estimator for this limit and establish its consistency, in particular, by Le Cam's third lemma. As an…