Adaptively Combining Randomized and External Control Data Using a Mixture Prior in the Presence of Heterogeneity
存在异质性时利用混合先验自适应结合随机试验与外部对照
When resources are limited in a randomized trial, a common strategy is to augment data from the control arm with external controls. We propose a hybrid group sequential Bayesian design that uses this approach to compare time-to-event distributions. The design allows between-treatment effects to differ between patient subgroups, and adaptively combines subgroups that have similar hazard functions. The aim is to reduce the control arm sample size without compromising the…