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存在干扰时的再随机化AI 解读

Covariates are widely used in randomized experiments to improve precision. However, in the presence of interference, where outcomes may depend on the treatment assignments of other units, standard covariate adjustment methods may fail to preserve desirable properties such as the no-harm property, meaning that incorporating covariates does not worsen estimator performance. Existing approaches that incorporate covariates under interference typically rely on specifying a…

存在样本流失时的随机化推断AI 解读

Randomization inference is a widely-used and appealing approach for analyzing treatment effects in randomized experiments, as it is finite-sample valid and does not require any distributional assumptions. However, naive application of randomization inference may suffer from severe size distortion in the presence of sample attrition, where outcome data are missing for some units. In this paper, we propose new, computationally efficient methods for randomization inference that…

生存结局治疗效应的随机化推断AI 解读

The log-rank test and Kaplan--Meier plot are standard tools for analyzing time-to-event data in randomized clinical trials, yet neither provides a summary of the magnitude of the treatment effect. Practitioners typically fill this gap by reporting a hazard ratio from a Cox proportional-hazards model or an acceleration factor from an accelerated failure time (AFT) model, but both require assumptions beyond those needed for the log-rank test or Kaplan--Meier estimator. We…

检测阴性设计的敏感性分析AI 解读

The test-negative design has become popular for evaluating the effectiveness of post-licensure vaccines using observational data. In addition to its logistical convenience on data collection, the design is also believed to control for the differential health-care-seeking behavior between vaccinated and unvaccinated individuals, an important while often unmeasured confounder between the vaccination and infection. Hence, the design has been employed routinely to monitor…

结合秩统计量的个体处理效应分布随机化检验AI 解读

What proportion of treated units actually benefited from an experimental intervention? What is the median or the largest individual treatment effect? This paper develops methods for answering such questions about the distribution of individual causal effects in randomized experiments. Existing approaches require the analyst to select a rank-based test statistic before observing the data. A poor choice can substantially reduce power, while searching over multiple test…

基于设计的嵌套工具变量分析AI 解读

Two binary instrumental variables (IVs) are nested if individuals who comply under one binary IV also comply under the other. This situation often arises when the two IVs represent different intensities of encouragement or discouragement to take the treatment, with one stronger than the other. In a nested IV structure, treatment effects can be identified for two latent subgroups: always-compliers and switchers. Always-compliers are individuals who comply even under the…

多类实验中个体处理效应分布与分位数的改进推断AI 解读

Understanding treatment effect heterogeneity has become increasingly important in many fields. In this paper we study distributions and quantiles of individual treatment effects to provide a more comprehensive and robust understanding of treatment effects beyond usual averages, despite they are more challenging to infer due to nonidentifiability from observed data. Recent randomization-based approaches offer finite-sample valid inference for treatment effect distributions…

存在未观测空间变化混杂时处理效应的可识别性AI 解读

The study of causal effects in the presence of unmeasured spatially varying confounders has garnered increasing attention. However, a general framework for identifiability, which is critical for reliable causal inference from observational data, has yet to be advanced. In this paper, we study a linear model with various parametric model assumptions on the covariance structure between the unmeasured confounder and the exposure of interest. We establish identifiability of the…

自适应实验因果推断的设计本位理论AI 解读

Adaptive designs dynamically update treatment probabilities using information accumulated during the experiment. Existing theory for causal inference from adaptive experiments primarily assumes the superpopulation framework with independent and identically distributed units, and may not apply when the distribution of units evolves over time. This paper makes two contributions. First, we extend the literature to the finite-population framework, which allows for possibly…

跨实验与跨时间学习：应对 A/B 测试中的异质性AI 解读

A/B testing plays a central role in data-driven product development, guiding launch decisions for new features and designs. However, treatment effect estimates are often noisy due to short horizons, early stopping, and slowly accumulating long-tail metrics, making early conclusions unreliable. A natural remedy is to pool information across related experiments, but naive pooling potentially fails: within experiments, treatment effects may evolve over time, so mixing early and…

使用 t 检验进行单一处理簇下的聚类稳健推断AI 解读

This paper considers inference when there is a single treated cluster and a fixed number of control clusters, a setting that is common in empirical work, especially in difference-in-differences designs. We use the t-statistic and develop suitable critical values to conduct valid inference under weak assumptions allowing for unknown dependence within clusters. In particular, our inference procedure does not involve variance estimation. It only requires specifying the relative…

无混杂与重叠性同时失效时基于增广百分位自助法的稳健敏感性分析AI 解读

The identification of causal effects in observational studies typically relies on two standard assumptions: unconfoundedness and overlap. However, both assumptions are often questionable in practice: unconfoundedness is inherently untestable, and overlap may fail in the presence of extreme unmeasured confounding. While various approaches have been developed to address unmeasured confounding and extreme propensity scores separately, few methods accommodate simultaneous…

基于马氏距离的最优选择再随机化渐近理论AI 解读

Rerandomization, a design that utilizes pretreatment covariates and improves their balance between different treatment groups, has received attention recently in both theory and practice. From a survey by Bruhn and McKenzie (2009), there are at least two types of rerandomization that are used in practice: the first rerandomizes the treatment assignment until covariate imbalance is below a prespecified threshold; the second randomizes the treatment assignment multiple times…

灵活匹配设计下观察性研究的敏感性分析AI 解读

Observational studies provide invaluable opportunities to draw causal inference, but they may suffer from biases due to pretreatment difference between treated and control units. Matching is a popular approach to reduce observed covariate imbalance. To tackle unmeasured confounding, a sensitivity analysis is often conducted to investigate how robust a causal conclusion is to the strength of unmeasured confounding. For matched observational studies, Rosenbaum proposed a…

匹配观察性研究中隐性偏差分位数的敏感性分析AI 解读

Causal conclusions from observational studies may be sensitive to unmeasured confounding. In such cases, a sensitivity analysis is often conducted, which tries to infer the minimum amount of hidden biases or the minimum strength of unmeasured confounding needed in order to explain away the observed association between treatment and outcome. If the needed bias is large, then the treatment is likely to have significant effects. The Rosenbaum sensitivity analysis is a modern…

用于评估平均与个体处理效应的随机化型 Z 估计AI 解读

Randomized experiments have been the gold standard for drawing causal inference. The conventional model-based approach has been one of the most popular ways for analyzing treatment effects from randomized experiments, which is often carried through inference for certain model parameters. In this paper, we provide a systematic investigation of model-based analyses for treatment effects under the randomization-based inference framework. This framework does not impose any…

早期疫苗试验中个体处理效应的随机化推断AI 解读

Randomization inference is a powerful tool in early phase vaccine trials when estimating the causal effect of a regimen against a placebo or another regimen. Randomization-based inference often focuses on testing either Fisher's sharp null hypothesis of no treatment effect for any participant or Neyman's weak null hypothesis of no sample average treatment effect. Many recent efforts have explored conducting exact randomization-based inference for other summaries of the…

超越尖锐零假设的随机化推断：有界零假设与个体处理效应分位数AI 解读

Randomization inference (RI) is typically interpreted as testing Fisher's "sharp" null hypothesis that all unit-level effects are exactly zero. This hypothesis is often criticized as restrictive and implausible, making its rejection scientifically uninteresting. We show, however, that many randomization tests are also valid for a "bounded" null hypothesis under which the unit-level effects are all non-positive (or all non-negative) but are otherwise heterogeneous. In…

分层随机实验与匹配观测研究中的个体处理效应分位数AI 解读

Evaluating the treatment effects has become an important topic for many applications. However, most existing literature focuses mainly on the average treatment effects. When the individual effects are heavy-tailed or have outlier values, not only may the average effect not be appropriate for summarizing the treatment effects, but also the conventional inference for it can be sensitive and possibly invalid due to poor large-sample approximations. In this paper we focus on…

再随机化实验的功效与样本量计算AI 解读

Power analyses are an important aspect of experimental design, because they help determine how experiments are implemented in practice. It is common to specify a desired level of power and compute the sample size necessary to obtain that power. Such calculations are well-known for completely randomized experiments, but there can be many benefits to using other experimental designs. For example, it has recently been established that rerandomization, where subjects are…

协变量不平衡趋零且协变量数量增长时的再随机化AI 解读

Completely randomized experiments have been the gold standard for drawing causal inference because they can balance all potential confounding on average. However, they may suffer from unbalanced covariates for realized treatment assignments. Rerandomization, a design that rerandomizes the treatment assignment until a prespecified covariate balance criterion is met, has recently got attention due to its easy implementation, improved covariate balance and more efficient…

删失结局的随机化检验：重新理解 Logrank 检验AI 解读

Two-sample tests with censored outcomes are a classical topic in statistics with wide use even in cutting edge applications. There are at least two modes of inference used to justify two-sample tests. One is usual superpopulation inference assuming that units are independent and identically distributed (i.i.d.) samples from some superpopulation; the other is finite population inference that relies on the random assignments of units into different groups. When randomization…

调查实验中的拒绝式抽样、再随机化与回归调整AI 解读

Classical randomized experiments, equipped with randomization-based inference, provide assumption-free inference for treatment effects. They have been the gold standard for drawing causal inference and provide excellent internal validity. However, they have also been criticized for questionable external validity, in the sense that the conclusion may not generalize well to a larger population. The randomized survey experiment is a design tool that can help mitigate this…