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纵向队列完全依从性因果效应：逆概率治疗加权与 G 估计比较AI 解读

Medication adherence is essential to ensure treatment effectiveness, but too often in routine care non-adherence compromises the desired outcome. We explore longitudinal causal modelling using observational data to estimate the time-varying effects of continuous drug adherence measures on health outcomes over a sustained period. The goal of such analyses is to quantify the potential impact of interventions to improve adherence on long-term health. We consider two established…

利用凝聚型层次聚类选择有效工具变量AI 解读

We propose a procedure which combines hierarchical clustering with a test of overidentifying restrictions for selecting valid instrumental variables (IV) from a large set of IVs. Some of these IVs may be invalid in that they fail the exclusion restriction. We show that if the largest group of IVs is valid, our method achieves oracle properties. Unlike existing techniques, our work deals with multiple endogenous regressors. Simulation results suggest an advantageous…

纵向重复测量数据中针对假设性目标量的工具变量方法：STEP 1 试验应用AI 解读

The STEP 1 randomized trial evaluated the effect of taking semaglutide vs placebo on body weight over a 68 week duration. As with any study evaluating an intervention delivered over a sustained period, non-adherence was observed. This was addressed in the original trial analysis within the Estimand Framework by viewing non-adherence as an intercurrent event. The primary analysis applied a treatment policy strategy which viewed it as an aspect of the treatment regimen, and…

多暴露线性模型中的有效工具变量选择：自适应 Lasso 与中位数的中位数估计量AI 解读

In a linear instrumental variables (IV) setting for estimating the causal effects of multiple confounded exposure/treatment variables on an outcome, we investigate the adaptive Lasso method for selecting valid instrumental variables from a set of available instruments that may contain invalid ones. An instrument is invalid if it fails the exclusion conditions and enters the model as an explanatory variable. We extend the results as developed in Windmeijer et al. (2019) for…