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一般干扰下分位数暴露效应的设计型估计与推断AI 解读

Many applications in public health, environmental science, and economics feature spillovers across connected units, violating the Stable Unit Treatment Value Assumption (SUTVA) underlying classical quantile treatment effect methods. We develop a general framework for defining, estimating, and conducting inference for quantile exposure effects (QEEs) under network interference, encompassing quantile direct and spillover effects as leading cases. Studying QEEs under…

存在中间事件时利用多状态数据估计路径处理效应AI 解读

During clinical trials evaluating a drug's effect on a survival endpoint, intermediate events often occur in addition to the primary event. The treatment can exert its effect on the primary endpoint along multiple pathways through intermediate events. Assumptions for identifying mediation effects, such as sequential ignorability in natural effects or the dismissible components condition in separable effects, fail because intermediate events act as treatment-induced…

ICH E9（R1）框架下随机试验累积发生率与处理效应的推断AI 解读

In randomized controlled trials (RCTs) that focus on time-to-event outcomes, intercurrent events can arise in two ways: as semi-competing events, which modify the hazard of the primary outcome events, or as competing events, which make the definition of the primary outcome events unclear. Although five strategies have been proposed in the ICH E9 (R1) addendum to address intercurrent events in RCTs, these strategies are not easily applicable to time-to-event outcomes when…

借助辅助数据识别断点回归设计中的平均因果效应AI 解读

Regression discontinuity designs are widely used when treatment assignment is determined by whether a running variable exceeds a predefined threshold. However, most research focuses on estimating local causal effects at the threshold, leaving the challenge of identifying treatment effects away from the cutoff largely unaddressed. The primary difficulty in this context is that the treatment assignment is deterministically defined by the running variable, violating the…

利用多状态模型分解半竞争风险中的可分离路径效应AI 解读

Semi-competing risks refer to the phenomenon where a primary event (such as mortality) can ``censor'' an intermediate event (such as relapse of a disease), but not vice versa. Under the multi-state model, the primary event consists of two specific types: the direct outcome event and an indirect outcome event developed from intermediate events. Within this framework, we show that the total treatment effect on the cumulative incidence of the primary event can be decomposed…

半竞争风险下的直接与间接处理效应AI 解读

Semi-competing risks refer to the phenomenon that the terminal event (such as death) can censor the non-terminal event (such as disease progression) but not vice versa. The treatment effect on the terminal event can be delivered either directly following the treatment or indirectly through the non-terminal event. We consider two strategies to decompose the total effect into a direct effect and an indirect effect under the framework of mediation analysis in completely…

死亡截断与未测混杂下的因果推断AI 解读

Clinical studies sometimes encounter truncation by death, rendering outcomes undefined. Statistical analysis based solely on observed survivors may give biased results because the characteristics of survivors differ between treatment groups. By principal stratification, the survivor average causal effect was proposed as a causal estimand defined in always-survivors. However, this estimand is not identifiable when there is unmeasured confounding between the treatment…

高维数据下协变量特定处理效应的模型辅助推断AI 解读

Covariate-specific treatment effects (CSTEs) represent heterogeneous treatment effects across subpopulations defined by certain selected covariates. In this article, we consider marginal structural models where CSTEs are linearly represented using a set of basis functions of the selected covariates. We develop a new approach in high-dimensional settings to obtain not only doubly robust point estimators of CSTEs, but also model-assisted confidence intervals, which are valid…