Improve Power of Knockoffs with Annotation Information of Covariates
利用协变量注释信息提高 Knockoff 变量选择的功效
Genome-wide association studies (GWAS) often find association signals between many genetic variants and traits of interest in a genomic region. Functional annotations of these variants provide valuable prior information that helps prioritize biologically relevant variants and enhances the power to detect causal variants. However, due to substantial correlations among these variants, a critical question is how to rigorously control the false discovery rate while effectively…