A Random Effects Model-based Method of Moments Estimation of Causal Effect in Mendelian Randomization Studies
孟德尔随机化因果效应的随机效应模型矩估计
Recent advances in genotyping technology have delivered a wealth of genetic data, which is rapidly advancing our understanding of the underlying genetic architecture of complex diseases. Mendelian Randomization (MR) leverages such genetic data to estimate the causal effect of an exposure factor on an outcome from observational studies. In this paper, we utilize genetic correlations to summarize information on a large set of genetic variants associated with the exposure…