On Cluster Randomized Trials with the Desirability of Outcome Ranking (DOOR) Endpoints
采用结局优劣排序端点的整群随机试验
Cluster randomized trials are widely used when individual randomization is logistically infeasible or when correlations between observations cannot be ignored, especially in fields such as ophthalmology, infectious disease, vaccine research, and sociology. The desirability of outcome ranking (DOOR) framework evaluates patient-centric benefit-risk using an ordinal outcome and a Wilcoxon-Mann-Whitney statistic-based approach to compare outcome distributions between…