Recurrent Events Modeling Based on a Reflected Brownian Motion with Application to Hypoglycemia
基于反射布朗运动的重复事件模型及其低血糖应用
Patients with type 2 diabetes need to closely monitor blood sugar levels as their routine diabetes self-management. Although many treatment agents aim to tightly control blood sugar, hypoglycemia often stands as an adverse event. In practice, patients can observe hypoglycemic events more easily than hyperglycemic events due to the perception of neurogenic symptoms. We propose to model each patient's observed hypoglycemic event as a lower-boundary crossing event for a…