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边际处理效应与异质性处理效应的联合估计AI 解读

Randomized clinical trials typically aim to estimate a marginal treatment effect. While covariate adjustment can improve precision, it may change the estimand in nonlinear models due to noncollapsibility, leading to conditional rather than marginal treatment effects. At the same time, identifying prognostic and predictive covariates is important for understanding treatment effect heterogeneity and informing clinical decision-making. Keeping marginal interpretability while…

非正态变换模型下的协变量调整边际推断AI 解读

Although treatment effects can be estimated from observed outcome distributions obtained from proper randomization in clinical trials, covariate adjustment is recommended to increase precision. For important treatment effects, such as odds or hazard ratios, conditioning on covariates in binary logistic or proportional hazards models changes the interpretation of the treatment effect and conditioning on different sets of covariates renders the resulting effect estimates…

面向一般响应类型的模型化因果特征选择AI 解读

Discovering causal relationships from observational data is a fundamental yet challenging task. Invariant causal prediction (ICP, Peters et al., 2016) is a method for causal feature selection which requires data from heterogeneous settings and exploits that causal models are invariant. ICP has been extended to general additive noise models and to nonparametric settings using conditional independence tests. However, the latter often suffer from low power (or poor type I error…

森林型异质性处理效应估计为何有效？AI 解读

Estimation of heterogeneous treatment effects (HTE) is of prime importance in many disciplines, ranging from personalized medicine to economics among many others. Random forests have been shown to be a flexible and powerful approach to HTE estimation in both randomized trials and observational studies. In particular "causal forests", introduced by Athey, Tibshirani and Wager (2019), along with the R implementation in package grf were rapidly adopted. A related approach,…

利用模型森林估计观测数据的异质性处理效应AI 解读

The estimation of heterogeneous treatment effects (HTEs) has attracted considerable interest in many disciplines, most prominently in medicine and economics. Contemporary research has so far primarily focused on continuous and binary responses where HTEs are traditionally estimated by a linear model, which allows the estimation of constant or heterogeneous effects even under certain model misspecifications. More complex models for survival, count, or ordinal outcomes require…