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多参数广义耙估计的最优两阶段抽样设计AI 解读

Large observational datasets, including those derived from electronic health records, are a valuable resource for medical research but are often affected by missingness, measurement error, and misclassification. Two-phase sampling with generalized raking (GR) estimation is an efficient and robust approach to statistical inference in such settings. In this approach, variables that are unavailable or measured with error in a large phase 1 cohort are obtained with…

替代标签驱动推断：正则化与自适应性AI 解读

High-quality labeled data are essential for reliable statistical inference, but are often limited by validation costs. While surrogate labels provide cost-effective alternatives, their noise can introduce non-negligible bias. To address this challenge, we propose the surrogate-powered inference (SPI) toolbox, a unified framework that leverages both the validity of high-quality labels and the abundance of surrogates to enable reliable statistical inference. SPI comprises…

通过分层改进最优子抽样AI 解读

Recent works have proposed optimal subsampling algorithms to improve computational efficiency in large datasets and to design validation studies in the presence of measurement error. Existing approaches generally fall into two categories: (i) designs that optimize individualized sampling rules, where unit-specific probabilities are assigned and applied independently, and (ii) designs based on stratified sampling with simple random sampling within strata. Focusing on the…

混杂变量缺失时的处理效应评估：双重稳健与传统缺失数据方法比较AI 解读

In pharmacoepidemiology, safety and effectiveness are frequently evaluated using readily available administrative and electronic health records data. In these settings, detailed confounder data are often not available in all data sources and therefore missing on a subset of individuals. Multiple imputation (MI) and inverse-probability weighting (IPW) are go-to analytical methods to handle missing data and are dominant in the biomedical literature. Doubly-robust methods,…