B-MASTER: Scalable Bayesian Multivariate Regression for Master Predictor Discovery in Colorectal Cancer Microbiome-Metabolite Profiles
B-MASTER:用于结直肠癌微生物组-代谢物谱主预测因子发现的可扩展贝叶斯多元回归
Motivation: The gut microbiome shapes cancer therapy response through its influence on host metabolism. While prior studies examine pairwise associations between individual genera and metabolites, there is limited methodology for identifying microbial genera that systematically regulate the overall metabolome. Scalable statistical tools are needed to uncover such system-level 'master predictors' in high-dimensional microbiome-metabolome data. Results: We introduce B-MASTER,…