Augmented Binary Method for Basket Trials (ABBA)
篮式试验的增强二元方法(ABBA)
In several clinical areas, traditional clinical trials often use a responder outcome, a composite endpoint that involves dichotomising a continuous measure. An augmented binary method that improves power whilst retaining the original responder endpoint has previously been proposed. The method leverages information from the the undichotomised component to improve power. We extend this method for basket trials, which are gaining popularity in many clinical areas. For clinical…