Outcomes truncated by death in RCTs: a simulation study on the survivor average causal effect
随机对照试验中死亡截断结局:幸存者平均因果效应的模拟研究
Continuous outcome measurements truncated by death present a challenge for the estimation of unbiased treatment effects in randomized controlled trials (RCTs). One way to deal with such situations is to estimate the survivor average causal effect (SACE), but this requires making non-testable assumptions. Motivated by an ongoing RCT in very preterm infants with intraventricular hemorrhage, we performed a simulation study to compare a SACE estimator with complete case analysis…