Inferring Comprehensive Cohort Causal Effects in the Presence of Unmeasured Confounding and Missing Outcomes
未测混杂与结局缺失下的综合队列因果效应推断
This paper presents a methodological framework for estimating the comprehensive cohort causal effect (CCCE) in mixed-design clinical studies that combine randomized controlled trials (RCTs) and parallel observational study (OBS). Our approach is designed to evaluate robustness against unmeasured confounding in the OBS arm and to handle outcomes that are missing at random in either the RCT or OBS arm. By employing a semiparametric theory-based sensitivity analysis framework,…