Generalizing the Finkelstein-Schoenfeld Test to Incorporate Multiple Alternating Thresholds
引入多个交替阈值的 Finkelstein–Schoenfeld 检验推广
Composite endpoints consisting of both terminal and non-terminal events, such as death and hospitalization, are frequently used in cardiovascular clinical trials. The Finkelstein-Schoenfeld (FS) test provides a way to employ a hierarchical structure to combine fatal and non-fatal events by giving death information an absolute priority, which may limit the contribution of clinically meaningful non-fatal events. To provide a more flexible alternative, we propose the…