Frequentist analysis of basket trials with one-sample Mantel-Haenszel procedures
基于单样本 Mantel–Haenszel 方法的篮式试验频率学派分析
Recent substantial advances of molecular targeted oncology drug development is requiring new paradigms for early-phase clinical trial methodologies to enable us to evaluate efficacy of several subtypes simultaneously and efficiently. The concept of the basket trial is getting of much attention to realize this requirement borrowing information across subtypes, which are called baskets. Bayesian approach is a natural approach to this end and indeed the majority of the existing…