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Treatment persistence drives estimator performance in longitudinal causal inference based on observational data: A simulation study

处理持续性如何影响纵向观察数据中的因果估计表现

Longitudinal clinical data are increasingly available, offering opportunities to study treatment effects over time but also raising challenges related to time-varying confounding and evolving treatment decisions. We investigate how longitudinal treatment dynamics affect causal effect estimation when baseline and longitudinal methods target different causal estimands. Using a structural causal model (SCM), we simulate data with time-varying confounding, binary treatment, and…

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Comparing Propensity Score-Based Methods in Estimating the Treatment Effects: A Simulation Study

倾向得分处理效应估计方法的模拟比较

In observational studies, the recorded treatment assignment is not purely random, but it is influenced by external factors such as patient characteristics, reimbursement policies, and existing guidelines. Therefore, the treatment effect can be estimated only after accounting for confounding factors. Propensity score (PS) methods are a family of methods that is widely used for this purpose. Although they are all based on the estimation of the a posteriori probability of…

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