Statistical Methods for Crossover Trials: A Review of Classical and Recent Developments
交叉试验的统计方法:经典与近期进展综述
A comprehensive review of the literature on crossover design is needed to highlight its evolution, applications, and methodological advancements across various fields. Given its widespread use in clinical trials and other research domains, understanding this design's challenges, assumptions, and innovations is essential for optimizing its implementation and ensuring accurate, unbiased results. This article extensively reviews the history and statistical inference methods for…