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Instrumental Variable Analysis in Underrepresented Subpopulations Powered by Knowledge Transfer

借助知识迁移增强代表性不足子群体的工具变量分析

Instrumental variable (IV) analysis in underrepresented target populations suffers from low statistical efficiency and weak IV bias due to limited sample size. Leveraging external knowledge from a source population with larger samples offers an appealing solution to this problem. We propose in this paper the KNowledge-powered IV Estimator for underrepresented Subpopulations (KNIVES), a framework that enhances the IV analysis for underrepresented subpopulations by…

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Denoising Data with Measurement Error Using a Reproducing Kernel-based Diffusion Model

基于再生核扩散模型的测量误差数据去噪

The ongoing technological revolution in measurement systems enables the acquisition of high-resolution samples in fields such as engineering, biology, and medicine. However, these observations are often subject to errors from measurement devices. Motivated by this challenge, we propose a denoising framework that employs diffusion models to generate denoised data whose distribution closely approximates the unobservable, error-free data, thereby permitting standard data…

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Statistical inference for the probability of necessity for causal attribution

因果归因中必要性概率的统计推断

To answer questions of "causes of effects", the probability of necessity was previously introduced for assessing whether an observed outcome was caused by an earlier treatment. However, statistical inference for the probability of necessity is understudied due to several difficulties, which hinder its application in practice. The evaluation of the probability of necessity involves the joint distribution of potential outcomes, and thus it is generally not point identified and…

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Identification and Estimation of Heterogeneous Interference Effects under Unknown Network

未知网络下异质性干扰效应的识别与估计

Interference--in which a unit's outcome is affected by the treatment of other units--poses significant challenges for the identification and estimation of causal effects. Most existing methods for estimating interference effects assume that the interference networks are known. In many practical settings, this assumption is unrealistic as such networks are typically latent. To address this challenge, we propose a novel framework for identifying and estimating heterogeneous…

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Causal Effect Identification and Inference with Endogenous Exposures and a Light-tailed Error

内生暴露与轻尾误差下的因果效应识别和推断

Endogeneity poses significant challenges in causal inference across various research domains. This paper proposes a novel approach to identify and estimate causal effects in the presence of endogeneity. We consider a structural equation with endogenous exposures and an additive error term. Assuming the light-tailedness of the error term, we show that the causal effect can be identified by contrasting extreme conditional quantiles of the outcome given the exposures. Unlike…

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Debiased Estimating Equation Method for Robust and Efficient Mendelian Randomization Using a Large Number of Correlated Weak and Invalid Instruments

使用大量相关弱工具和无效工具的稳健有效孟德尔随机化:去偏估计方程法

Mendelian randomization (MR) is a widely used tool for causal inference in the presence of unmeasured confounders, which uses single nucleotide polymorphisms (SNPs) as instrumental variables to estimate causal effects. However, SNPs often have weak effects on complex traits, leading to bias in existing MR analysis when weak instruments are included. In addition, existing MR methods often restrict analysis to independent SNPs via linkage disequilibrium clumping and result in…

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Regularized Multi-LLMs Collaboration for Enhanced Score-based Causal Discovery

正则化多大语言模型协作辅助基于评分的因果发现

As the significance of understanding the cause-and-effect relationships among variables increases in the development of modern systems and algorithms, learning causality from observational data has become a preferred and efficient approach over conducting randomized control trials. However, purely observational data could be insufficient to reconstruct the true causal graph. Consequently, many researchers tried to utilise some form of prior knowledge to improve causal…

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