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基于体素级BOLD信号的区域功能连接混合模型估计AI 解读

Resting-state brain functional connectivity quantifies the synchrony between activity patterns of different brain regions. In functional magnetic resonance imaging, each region comprises a set of spatially contiguous voxels at which blood-oxygen-level-dependent signals are acquired. The ubiquitous Correlation of Averages (CA) estimator, and other similar metrics, are computed from spatially aggregated signals within each region, and remain the quantifications of…

含协变量的高斯图回归模型的凸估计AI 解读

Gaussian graphical models (GGMs) are widely used to recover the conditional independence structure among random variables. Recent work has sought to incorporate auxiliary covariates to improve estimation, particularly in applications such as co-expression quantitative trait locus (eQTL) studies, where both gene expression levels and their conditional dependence structure may be influenced by genetic variants. Existing approaches to covariate-adjusted GGMs either restrict…