Can the potential benefit of individualizing treatment be assessed using trial summary statistics alone?
仅凭试验汇总统计能否评估个体化治疗的潜在收益?
Individualizing treatment assignment can improve outcomes for diseases with patient-to-patient variability in comparative treatment effects. When a clinical trial demonstrates that some patients improve on treatment while others do not, it is tempting to assume that treatment effect heterogeneity exists. However, if variability in response is mainly driven by factors other than treatment, investigating the extent to which covariate data can predict differential treatment…