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高维多研究、多模态协变量增强广义因子模型AI 解读

Latent factor models that integrate data from multiple sources/studies or modalities have garnered considerable attention across various disciplines. However, existing methods predominantly focus either on multi-study integration or multi-modality integration, rendering them insufficient for analyzing the diverse modalities measured across multiple studies. To address this limitation and cater to practical needs, we introduce a high-dimensional generalized factor model that…

高维协变量增强的过度离散多研究泊松因子模型AI 解读

Factor analysis for high-dimensional data is a canonical problem in statistics and has a wide range of applications. However, there is currently no factor model tailored to effectively analyze high-dimensional count responses with corresponding covariates across multiple studies, such as the single-cell sequencing dataset from a case-control study. In this paper, we introduce factor models designed to jointly analyze multiple studies by extracting study-shared and specified…

高维协变量增强的过度离散泊松因子模型AI 解读

The current Poisson factor models often assume that the factors are unknown, which overlooks the explanatory potential of certain observable covariates. This study focuses on high dimensional settings, where the number of the count response variables and/or covariates can diverge as the sample size increases. A covariate-augmented overdispersed Poisson factor model is proposed to jointly perform a high-dimensional Poisson factor analysis and estimate a large coefficient…