Dealing with positivity violations in mediation analysis via weighted controlled effects, with application to assessing immune correlates of protection in antigen-experienced participants
用加权控制效应处理中介分析的正值性违背:既往抗原暴露人群的免疫保护关联应用
Causal mediation analysis has become an important and increasingly used framework for evaluating candidate immune response biomarkers in vaccine research. A controlled effects approach has been proposed to estimate controlled risk curves under a counterfactual scenario in which the entire study population is vaccinated and their post-vaccination immune responses are set to a range of fixed levels. This framework performs well when the study population is antigenically naïve,…