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面向超高维数据的贝叶斯单变量引导稀疏回归AI 解读

Ultra-high-dimensional genomic studies require simultaneous identification of sparse signals, control of spurious discoveries, and computationally feasible inference when the number of predictors can reach hundreds of thousands or more. We propose Bayesian Univariate-Guided Sparse Regression (BUGS), a global--local shrinkage framework that incorporates marginal association information directly into the prior through continuous modulation of shrinkage. By embedding univariate…

BLOC：非凸惩罚稀疏协方差估计的全局优化框架AI 解读

We introduce BLOC (Black-box Optimization over Correlation matrices), a general framework for sparse covariance estimation with non-convex penalties. BLOC operates on the manifold of correlation matrices and reparameterizes it via an angular Cholesky mapping, transforming the positive-definite, unit-diagonal constraint into an unconstrained search over a Euclidean hyperrectangle. This enables gradient-free global optimization of diverse objectives, including…

MAPLE：基于 Mapper 的局部预测与数据驱动覆盖选择AI 解读

High dimensional biomedical data often exhibit nonlinear, heterogeneous, and manifold driven structures that challenge global parametric and tree-based models. We propose MAPLE (mapper-based Adaptive Prediction via Local Estimation), a localized prediction framework grounded in topological data analysis. The method is formulated as a nonparametric estimator of conditional class probabilities that adapts to the intrinsic geometry of the predictor space. Neighborhoods are…

超高维DNA甲基化数据中发育表观遗传衰老的监督低秩结构发现AI 解读

Ultra-high-dimensional array-based CpG methylation studies require statistical frameworks that simultaneously provide supervised structure discovery, interpretability, scalable latent-dimension identification, and computational feasibility. We propose SOLAR (Supervised Orthogonal Low-rank Adaptive Regression), a supervised low-rank latent-factor framework for identifying CpG-level methylation structure associated with residualized DNAm age. SOLAR combines orthogonal low-rank…

B-MASTER：用于结直肠癌微生物组-代谢物谱主预测因子发现的可扩展贝叶斯多元回归AI 解读

Motivation: The gut microbiome shapes cancer therapy response through its influence on host metabolism. While prior studies examine pairwise associations between individual genera and metabolites, there is limited methodology for identifying microbial genera that systematically regulate the overall metabolome. Scalable statistical tools are needed to uncover such system-level 'master predictors' in high-dimensional microbiome-metabolome data. Results: We introduce B-MASTER,…