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Understanding associations between paired high-dimensional longitudinal datasets is a fundamental yet challenging problem arising across scientific domains, including longitudinal multi-omic studies. The difficulty stems from the complex, time-varying cross-covariance structure coupled with high dimensionality, which complicates both model formulation and statistical estimation for association discovery. To address these challenges, we propose a new framework called…

异质轨迹的函数奇异值分解：健康领域案例AI 解读

Trajectory data, including time series and longitudinal measurements, are increasingly common in health-related domains such as biomedical research and epidemiology. Real-world trajectory data frequently exhibit heterogeneity across subjects such as patients, sites, and subpopulations, yet many traditional methods are not designed to accommodate such heterogeneity in data analysis. To address this, we propose a unified framework, termed Functional Singular Value…