Extrapolation of Relative Treatment Effects using Change-point Survival Models
利用变点生存模型外推相对治疗效应
Introduction: Modelling of relative treatment effects is an important aspect to consider when extrapolating the long-term survival outcomes of treatments. Flexible parametric models offer the ability to accurately model the observed data, however, the extrapolated relative treatment effects and subsequent survival function may lack face validity. Methods: We investigate the ability of change-point survival models to estimate changes in the relative treatment effects,…