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Machine-Learning-Powered Specification Testing in Linear Instrumental Variable Models

机器学习驱动的线性工具变量模型设定检验

The linear instrumental variable (IV) model is widely used in observational studies, yet its validity hinges on strong assumptions. Classical specification tests such as the Sargan-Hansen J test are limited to overidentified settings and are therefore not applicable in the common just-identified case, where the number of instruments is equal to the number of endogenous variables. We propose a novel test for the well-specification of the linear IV model under the assumption…

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Weak-instrument-robust subvector inference in instrumental variables regression: A subvector Lagrange multiplier test and properties of subvector Anderson-Rubin confidence sets

工具变量回归中的弱工具稳健子向量推断:LM 检验与 AR 置信集性质

We propose a weak-instrument-robust subvector Lagrange multiplier test for instrumental variables regression. We show that it is asymptotically size-correct under a technical condition or as the number of instruments grows to infinity. This is the first weak-instrument-robust subvector test for instrumental variables regression to recover the degrees of freedom of the commonly used non-weak-instrument-robust Wald test. Additionally, we provide a closed-form solution for…

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Domain Generalization and Adaptation in Intensive Care with Anchor Regression

重症监护中的锚回归域泛化与域适应

The performance of predictive models in clinical settings often degrades when deployed in new hospitals due to distribution shifts. This paper presents a large-scale study of causality-inspired domain generalization on heterogeneous multi-center intensive care unit (ICU) data. We apply anchor regression and introduce anchor boosting, a novel, tree-based nonlinear extension, to a large dataset comprising 400,000 patients from nine distinct ICU databases. We find that anchor…

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Inference for Heterogeneous Treatment Effects with Efficient Instruments and Machine Learning

利用有效工具变量与机器学习推断异质处理效应

We introduce a new instrumental variable (IV) estimator for heterogeneous treatment effects in the presence of endogeneity. Our estimator is based on double/debiased machine learning (DML) and uses efficient machine learning instruments (MLIV) and kernel smoothing. We prove consistency and asymptotic normality of our estimator and also construct confidence sets that are more robust towards weak IV. Along the way, we also provide an accessible discussion of the corresponding…

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Causal Invariance Learning via Efficient Nonconvex Optimization

通过高效非凸优化学习因果不变性

Identifying the causal relationship among variables from observational data is an important yet challenging task. This work focuses on identifying the direct causes of an outcome and estimating their magnitude, i.e., learning the causal outcome model. Data from multiple environments provide valuable opportunities to uncover causality by exploiting the invariance principle that the causal outcome model holds across heterogeneous environments. Based on the invariance…

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Causality Pursuit from Heterogeneous Environments via Neural Adversarial Invariance Learning

通过神经对抗不变性学习从异质环境中探寻因果关系

Pursuing causality from data is a fundamental problem in scientific discovery, treatment intervention, and transfer learning. This paper introduces a novel algorithmic method for addressing nonparametric invariance and causality learning in regression models across multiple environments, where the joint distribution of response variables and covariates varies, but the conditional expectations of outcome given an unknown set of quasi-causal variables are invariant. The…

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Causality-Inspired Robustness for Nonlinear Models via Representation Learning

因果启发的非线性模型稳健性:基于表征学习

Distributional robustness is a central goal of prediction algorithms due to the prevalent distribution shifts in real-world data. The prediction model aims to minimize the worst-case risk among a class of distributions, a.k.a., an uncertainty set. Causality provides a modeling framework with a rigorous robustness guarantee in the above sense, where the uncertainty set is data-driven rather than pre-specified as in traditional distributional robustness optimization. However,…

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Model Selection over Partially Ordered Sets

偏序集合上的模型选择

In problems such as variable selection and graph estimation, models are characterized by Boolean logical structure such as presence or absence of a variable or an edge. Consequently, false positive error or false negative error can be specified as the number of variables/edges that are incorrectly included or excluded in an estimated model. However, there are several other problems such as ranking, clustering, and causal inference in which the associated model classes do not…

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Causality-oriented robustness: exploiting general noise interventions

面向因果结构的稳健预测:利用一般噪声干预

Since distribution shifts are common in real-world applications, there is a pressing need to develop prediction models that are robust against such shifts. Existing frameworks, such as empirical risk minimization or distributionally robust optimization, either lack generalizability for unseen distributions or rely on postulated distance measures. Alternatively, causality offers a data-driven and structural perspective to robust predictions. However, the assumptions necessary…

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Characterization and Greedy Learning of Gaussian Structural Causal Models under Unknown Interventions

未知干预下高斯结构因果模型的刻画与贪心学习

We consider the problem of recovering the causal structure underlying observations from different experimental conditions when the targets of the interventions in each experiment are unknown. We assume a linear structural causal model with additive Gaussian noise and consider interventions that perturb their targets while maintaining the causal relationships in the system. Different models may entail the same distributions, offering competing causal explanations for the…

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Treatment Effect Estimation with Observational Network Data using Machine Learning

利用机器学习估计观测网络数据中的处理效应

Causal inference methods for treatment effect estimation usually assume independent units. However, this assumption is often questionable because units may interact, resulting in spillover effects between them. We develop augmented inverse probability weighting (AIPW) for estimation and inference of the expected average treatment effect (EATE) with observational data from a single (social) network with spillover effects. In contrast to overall effects such as the global…

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Ancestor regression in structural vector autoregressive models

结构向量自回归模型中的祖先回归

We present a new method for causal discovery in linear structural vector autoregressive models. We adapt an idea designed for independent observations to the case of time series while retaining its favorable properties, i.e., explicit error control for false causal discovery, at least asymptotically. We apply our method to several real-world bivariate time series datasets and discuss its findings which mostly agree with common understanding. The arrow of time in a model can…

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Assessing the overall and partial causal well-specification of nonlinear additive noise models

评估非线性加性噪声模型的整体与局部因果设定正确性

We propose a method to detect model misspecifications in nonlinear causal additive and potentially heteroscedastic noise models. We aim to identify predictor variables for which we can infer the causal effect even in cases of such misspecification. We develop a general framework based on knowledge of the multivariate observational data distribution. We then propose an algorithm for finite sample data, discuss its asymptotic properties, and illustrate its performance on…

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Robustness Against Weak or Invalid Instruments: Exploring Nonlinear Treatment Models with Machine Learning

对弱工具变量或无效工具变量的稳健性:利用机器学习探索非线性治疗模型

We discuss causal inference for observational studies with possibly invalid instrumental variables. We propose a novel methodology called two-stage curvature identification (TSCI) by exploring the nonlinear treatment model with machine learning. {The first-stage machine learning enables improving the instrumental variable's strength and adjusting for different forms of violating the instrumental variable assumptions.} The success of TSCI requires the instrumental variable's…

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Confidence and Uncertainty Assessment for Distributional Random Forests

分布随机森林的置信与不确定性评估

The Distributional Random Forest (DRF) is a recently introduced Random Forest algorithm to estimate multivariate conditional distributions. Due to its general estimation procedure, it can be employed to estimate a wide range of targets such as conditional average treatment effects, conditional quantiles, and conditional correlations. However, only results about the consistency and convergence rate of the DRF prediction are available so far. We characterize the asymptotic…

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Learning and scoring Gaussian latent variable causal models with unknown additive interventions

未知加性干预下高斯潜变量因果模型的学习与评分

With observational data alone, causal structure learning is a challenging problem. The task becomes easier when having access to data collected from perturbations of the underlying system, even when the nature of these is unknown. Existing methods either do not allow for the presence of latent variables or assume that these remain unperturbed. However, these assumptions are hard to justify if the nature of the perturbations is unknown. We provide results that enable scoring…

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On the pitfalls of Gaussian likelihood scoring for causal discovery

高斯似然评分用于因果发现的陷阱

We consider likelihood score-based methods for causal discovery in structural causal models. In particular, we focus on Gaussian scoring and analyze the effect of model misspecification in terms of non-Gaussian error distribution. We present a surprising negative result for Gaussian likelihood scoring in combination with nonparametric regression methods.

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TSCI: two stage curvature identification for causal inference with invalid instruments

TSCI:利用无效工具变量进行因果推断的两阶段曲率识别

TSCI implements treatment effect estimation from observational data under invalid instruments in the R statistical computing environment. Existing instrumental variable approaches rely on arguably strong and untestable identification assumptions, which limits their practical application. TSCI does not require the classical instrumental variable identification conditions and is effective even if all instruments are invalid. TSCI implements a two-stage algorithm. In the first…

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Ancestor regression in linear structural equation models

线性结构方程模型中的祖先回归

We present a new method for causal discovery in linear structural equation models. We propose a simple ``trick'' based on statistical testing in linear models that can distinguish between ancestors and non-ancestors of any given variable. Naturally, this can then be extended to estimating the causal order among all variables. We provide explicit error control for false causal discovery, at least asymptotically. This holds true even under Gaussianity, where other methods fail…

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Higher-order least squares: assessing partial goodness of fit of linear causal models

高阶最小二乘:评估线性因果模型的局部拟合优度

We introduce a simple diagnostic test for assessing the overall or partial goodness of fit of a linear causal model with errors being independent of the covariates. In particular, we consider situations where hidden confounding is potentially present. We develop a method and discuss its capability to distinguish between covariates that are confounded with the response by latent variables and those that are not. Thus, we provide a test and methodology for partial goodness of…

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Distributional Anchor Regression

分布式锚回归

Prediction models often fail if train and test data do not stem from the same distribution. Out-of-distribution (OOD) generalization to unseen, perturbed test data is a desirable but difficult-to-achieve property for prediction models and in general requires strong assumptions on the data generating process (DGP). In a causally inspired perspective on OOD generalization, the test data arise from a specific class of interventions on exogenous random variables of the DGP,…

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A Fast Non-parametric Approach for Local Causal Structure Learning

局部因果结构学习的快速非参数方法

We study the problem of causal structure learning with essentially no assumptions on the functional relationships and noise. We develop DAG-FOCI, a computationally fast algorithm for this setting that is based on the FOCI variable selection algorithm in~\cite{azadkia2021simple}. DAG-FOCI outputs the set of parents of a response variable of interest. We provide theoretical guarantees of our procedure when the underlying graph does not contain any (undirected) cycle containing…

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