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Berry-Esseen bounds for design-based causal inference with possibly diverging treatment levels and varying group sizes

处理水平可增长且组规模不同时设计型因果推断的 Berry–Esseen 界

Neyman (1923/1990) introduced the randomization model, which contains the notation of potential outcomes to define causal effects and a framework for large-sample inference based on the design of the experiment. However, the existing theory for this framework is far from complete, especially when the number of treatment levels diverges and the treatment group sizes vary. We provide a unified discussion of statistical inference under the randomization model with general…

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Causal inference in network experiments: regression-based analysis and design-based properties

网络实验中的因果推断:回归分析与设计性质

Network experiments are powerful tools for studying spillover effects, which avoid endogeneity by randomly assigning treatments to units over networks. However, it is non-trivial to analyze network experiments properly without imposing strong modeling assumptions. We show that regression-based point estimators and standard errors can have strong theoretical guarantees if the regression functions and robust standard errors are carefully specified to accommodate the…

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Design-based causal inference in bipartite experiments

二部实验中基于设计的因果推断

Bipartite experiments arise in various fields, in which the treatments are randomized over one set of units, while the outcomes are measured over another separate set of units. However, existing methods often rely on strong model assumptions about the data-generating process. Under the potential outcomes formulation, we explore design-based causal inference in bipartite experiments under weak assumptions by leveraging the sparsity structure of the bipartite graph that…

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When is it worthwhile to jackknife? Breaking the quadratic barrier for Z-estimators

何时值得使用刀切法?突破 Z 估计量的二次维度门槛

Resampling methods are especially well-suited to inference with estimators that provide only "black-box'' access. Jackknife is a form of resampling, widely used for bias correction and variance estimation, that is well-understood under classical scaling where the sample size $n$ grows for a fixed problem. We study its behavior in application to estimating functionals using high-dimensional $Z$-estimators, allowing both the sample size $n$ and problem dimension $d$ to…

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Identifying and bounding the probability of necessity for causes of effects with ordinal outcomes

有序结局下原因必要性概率的识别与界限

Although the existing causal inference literature focuses on the forward-looking perspective by estimating effects of causes, the backward-looking perspective can provide insights into causes of effects. In backward-looking causal inference, the probability of necessity measures the probability that a certain event is caused by the treatment given the observed treatment and outcome. Most existing results focus on binary outcomes. Motivated by applications with ordinal…

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Principal Stratification with Continuous Post-Treatment Variables: Nonparametric Identification and Semiparametric Estimation

连续处理后变量的主层分层:非参数识别与半参数估计

Post-treatment variables often complicate causal inference. They appear in many scientific problems, including noncompliance, truncation by death, mediation, and surrogate endpoint evaluation. Principal stratification is a strategy to address these challenges by adjusting for the potential values of the post-treatment variables, defined as the principal strata. It allows for characterizing treatment effect heterogeneity across principal strata and unveiling the mechanism of…

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Flexible sensitivity analysis for causal inference in observational studies subject to unmeasured confounding

未测量混杂下观察性研究因果推断的灵活敏感性分析

Causal inference with observational studies often suffers from unmeasured confounding, yielding biased estimators based on the unconfoundedness assumption. Sensitivity analysis assesses how the causal conclusions change with respect to different degrees of unmeasured confounding. Most existing sensitivity analysis methods work well for specific types of statistical estimation or testing strategies. We propose a flexible sensitivity analysis framework that can deal with…

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A decorrelation method for general regression adjustment in randomized experiments

随机实验中一般回归调整的去相关方法

We study regression adjustment with general function class approximations for estimating the average treatment effect in the design-based setting. Standard regression adjustment involves bias due to sample re-use, and this bias leads to behavior that is sub-optimal in the sample size, and/or imposes restrictive assumptions. Our main contribution is to introduce a novel decorrelation-based approach that circumvents these issues. We prove guarantees, both asymptotic and…

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A First Course in Causal Inference

因果推断入门课程

I developed the lecture notes based on my ``Causal Inference'' course at the University of California Berkeley over the past seven years. Since half of the students were undergraduates, my lecture notes only required basic knowledge of probability theory, statistical inference, and linear and logistic regressions.

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Mediation analysis with the mediator and outcome missing not at random

中介与结果非随机缺失时的中介分析

Mediation analysis is widely used for investigating direct and indirect causal pathways through which an effect arises. However, many mediation analysis studies are challenged by missingness in the mediator and outcome. In general, when the mediator and outcome are missing not at random, the direct and indirect effects are not identifiable without further assumptions. In this work, we study the identifiability of the direct and indirect effects under some interpretable…

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Real Effect or Bias? Best Practices for Evaluating the Robustness of Real-World Evidence through Quantitative Sensitivity Analysis for Unmeasured Confounding

真实效应还是偏差?用未测混杂定量敏感性分析评估真实世界证据

The assumption of no unmeasured confounders is a critical but unverifiable assumption required for causal inference yet quantitative sensitivity analyses to assess robustness of real-world evidence remains underutilized. The lack of use is likely in part due to complexity of implementation and often specific and restrictive data requirements required for application of each method. With the advent of sensitivity analyses methods that are broadly applicable in that they do…

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A randomization-based theory for preliminary testing of covariate balance in controlled trials

随机试验协变量平衡预检验的随机化理论

Randomized trials balance all covariates on average and provide the gold standard for estimating treatment effects. Chance imbalances nevertheless exist more or less in realized treatment allocations and intrigue an important question: what should we do in case the treatment groups differ with respect to some important baseline characteristics? A common strategy is to conduct a {\it preliminary test} of the balance of baseline covariates after randomization, and invoke…

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No star is good news: A unified look at rerandomization based on $p$-values from covariate balance tests

没有显著星号是好消息:基于协变量平衡检验 p 值的再随机化

Modern social and biomedical scientific publications require the reporting of covariate balance tables with not only covariate means by treatment group but also the associated $p$-values from significance tests of their differences. The practical need to avoid small $p$-values renders balance check and rerandomization by hypothesis testing standards an attractive tool for improving covariate balance in randomized experiments. Despite the intuitiveness of such practice and…

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When is the estimated propensity score better? High-dimensional analysis and bias correction

何时估计倾向得分更好?高维分析与偏差校正

Anecdotally, using an estimated propensity score is superior to the true propensity score in estimating the average treatment effect based on observational data. However, this claim comes with several qualifications: it holds only if propensity score model is correctly specified and the number of covariates $d$ is small relative to the sample size $n$. We revisit this phenomenon by studying the inverse propensity score weighting (IPW) estimator based on a logistic model with…

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An instrumental variable method for point processes: generalised Wald estimation based on deconvolution

点过程的工具变量方法:基于反卷积的广义 Wald 估计

Point processes are probabilistic tools for modeling event data. While there exists a fast-growing literature studying the relationships between point processes, it remains unexplored how such relationships connect to causal effects. In the presence of unmeasured confounders, parameters from point process models do not necessarily have causal interpretations. We propose an instrumental variable method for causal inference with point process treatment and outcome. We define…

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Power and Sample Size Calculations for Rerandomization

再随机化实验的功效与样本量计算

Power analyses are an important aspect of experimental design, because they help determine how experiments are implemented in practice. It is common to specify a desired level of power and compute the sample size necessary to obtain that power. Such calculations are well-known for completely randomized experiments, but there can be many benefits to using other experimental designs. For example, it has recently been established that rerandomization, where subjects are…

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Covariate adjustment in multi-armed, possibly factorial experiments

多处理臂及析因实验中的协变量调整

Randomized experiments are the gold standard for causal inference, and justify simple comparisons across treatment groups. Regression adjustment provides a convenient way to incorporate covariate information for additional efficiency. This article provides a unified account of its utility for improving estimation efficiency in multi-armed experiments. We start with the commonly used additive and fully interacted models for regression adjustment, and clarify the trade-offs…

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Bayesian Causal Inference: A Critical Review

贝叶斯因果推断:批判性综述

This paper provides a critical review of the Bayesian perspective of causal inference based on the potential outcomes framework. We review the causal estimands, identification assumptions, the general structure of Bayesian inference of causal effects, and sensitivity analysis. We highlight issues that are unique to Bayesian causal inference, including the role of the propensity score, definition of identifiability, the choice of priors in both low and high dimensional…

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Same Root Different Leaves: Time Series and Cross-Sectional Methods in Panel Data

同根异叶:面板数据中的时间序列与横截面方法

A central goal in social science is to evaluate the causal effect of a policy. One dominant approach is through panel data analysis in which the behaviors of multiple units are observed over time. The information across time and space motivates two general approaches: (i) horizontal regression (i.e., unconfoundedness), which exploits time series patterns, and (ii) vertical regression (e.g., synthetic controls), which exploits cross-sectional patterns. Conventional wisdom…

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Posterior Predictive Propensity Scores and $p$-Values

后验预测倾向得分与 p 值

\citet{Rosenbaum83ps} introduced the notion of the propensity score and discussed its central role in causal inference with observational studies. Their paper, however, caused a fundamental incoherence with an early paper by \citet{Rubin78}, which showed that the propensity score does not play any role in the Bayesian analysis of unconfounded observational studies if the priors on the propensity score and outcome models are independent. Despite the serious efforts made in…

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Estimation based on nearest neighbor matching: from density ratio to average treatment effect

基于最近邻匹配的估计:从密度比到平均处理效应

Nearest neighbor (NN) matching as a tool to align data sampled from different groups is both conceptually natural and practically well-used. In a landmark paper, Abadie and Imbens (2006) provided the first large-sample analysis of NN matching under, however, a crucial assumption that the number of NNs, $M$, is fixed. This manuscript reveals something new out of their study and shows that, once allowing $M$ to diverge with the sample size, an intrinsic statistic in their…

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Regression-based causal inference with factorial experiments: estimands, model specifications, and design-based properties

析因实验的回归因果推断:目标量、模型设定与设计性质

Factorial designs are widely used due to their ability to accommodate multiple factors simultaneously. The factor-based regression with main effects and some interactions is the dominant strategy for downstream data analysis, delivering point estimators and standard errors via one single regression. Justification of these convenient estimators from the design-based perspective requires quantifying their sampling properties under the assignment mechanism conditioning on the…

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Reconciling design-based and model-based causal inferences for split-plot experiments

协调裂区试验中的设计型与模型型因果推断

The split-plot design assigns different interventions at the whole-plot and sub-plot levels, respectively, and induces a group structure on the final treatment assignments. A common strategy is to use the OLS fit of the outcome on the treatment indicators coupled with the robust standard errors clustered at the whole-plot level. It does not give consistent estimator for the causal effects of interest when the whole-plot sizes vary. Another common strategy is to fit the…

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Model-assisted analyses of cluster-randomized experiments

整群随机实验的模型辅助分析

Cluster-randomized experiments are widely used due to their logistical convenience and policy relevance. To analyze them properly, we must address the fact that the treatment is assigned at the cluster level instead of the individual level. Standard analytic strategies are regressions based on individual data, cluster averages, and cluster totals, which differ when the cluster sizes vary. These methods are often motivated by models with strong and unverifiable assumptions,…

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