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插补就够了：平均处理效应估计的双稳健、半参数有效性与自动协变量平衡AI 解读

Imputation-based causal estimation is typically viewed as relying exclusively on an outcome model, in contrast to augmented inverse-probability weighting, whose consistency is protected by fitting two nuisance models. This paper argues that this view can be misleading by highlighting a hidden dual weighting structure in least-squares sieve regression imputation. Although only outcome regressions are explicitly fitted, the resulting imputation estimator admits an exact…

双侧随机化设计中的因果推断：析因回归、双向聚类与协变量调整AI 解读

We study randomized experiments involving two interacting populations, such as buyers and sellers in a marketplace. In the two-sided experiments we consider, we randomize the two populations separately and independently. For a pair consisting of one member from each population, the two assignments jointly determine one of four exposure conditions. Under a local interference assumption, we consider a broad class of linear estimands, including total, interaction, and buyer-…

用于观察研究因果推断的 CP 图AI 解读

Under the canonical setting of observational studies for causal inference, we derive a set of exact representations for pairwise differences among weighted average treatment effects as covariances between the conditional average treatment effect and the propensity score, up to positive scaling factors. These covariance representations bridge the two core concepts in causal inference with observational studies. They immediately imply that (i) the average treatment effect is…

用于多结果因果推断的逆回归AI 解读

With multiple outcomes in empirical research, a common strategy is to define a composite outcome as a weighted average of the original outcomes. However, the choices of weights are often subjective and can be controversial. We propose an inverse regression strategy for causal inference with multiple outcomes. The key idea is to regress the treatment on the outcomes, which is the inverse of the standard regression of the outcomes on the treatment. Although this strategy is…

交叉设计的系统分析：因果效应、有效估计与稳健推断AI 解读

Crossover designs randomly assign each unit to receive a sequence of treatments. By comparing outcomes within the same unit, these designs can effectively eliminate between-unit variation and facilitate the identification of both instantaneous effects of current treatments and carryover effects from past treatments. They are widely used in traditional biomedical studies and are increasingly adopted in modern digital platforms. However, standard analyses of crossover designs…

协变量平衡的再随机化如何缓解回归调整中的显著性操纵AI 解读

Rerandomization enforces covariate balance across treatment groups in the design stage of experiments. Despite its intuitive appeal, its theoretical justification remains unsatisfying because its benefits of improving efficiency for estimating the average treatment effect diminish if we use regression adjustment in the analysis stage. To strengthen the theory of rerandomization, we show that it mitigates false discoveries resulting from $p$-hacking caused by strategically…

混合解释变量下的误设回归：稳健推断与因果解释AI 解读

For analytic convenience, existing statistical frameworks either assume random or fixed regressors. However, it is a little awkward that they do not cover the practical case of estimating the average treatment effect in experiments with randomized treatments and non-randomized, fixed pretreatment covariates. We unify the literature by providing the theory for regressions with mixed regressors that contain both random and fixed components. Importantly, our theory allows for…

处理与结果非随机缺失时，工具变量模型的可识别性AI 解读

The instrumental variable model of Imbens and Angrist (1994) and Angrist et al. (1996) identifies the local average treatment effect, also known as the complier average causal effect (CACE). In practice, however, the treatment and outcome are often missing, and when they are missing not at random (MNAR), the CACE is generally not identifiable without further assumptions, because the underlying data distribution itself cannot be recovered. We study when the CACE remains…

超越预测的良性过拟合：普通最小二乘插值估计量AI 解读

Recent advances in deep learning have highlighted the phenomenon of benign overfitting in overparameterized statistical models, sparking significant interest in understanding its foundations. Owing to its simplicity and practical relevance, the ordinary least squares (OLS) interpolator has become a key object of study for gaining theoretical insight into this phenomenon. While the properties of OLS are well understood in classical underparameterized settings, its behavior in…

随机饱和度设计中簇内与簇间溢出效应的估计AI 解读

Randomized saturation designs are two-stage experiments: they first randomly assign treatment probabilities over the clusters and then randomly assign the treatment to the units within the clusters. The existing literature on randomized saturation designs focuses on estimating within-cluster spillover effects by assuming away between-cluster spillover effects. However, the units may interact across clusters in many practical randomized saturation designs. A leading example…

检测阴性设计的敏感性分析AI 解读

The test-negative design has become popular for evaluating the effectiveness of post-licensure vaccines using observational data. In addition to its logistical convenience on data collection, the design is also believed to control for the differential health-care-seeking behavior between vaccinated and unvaccinated individuals, an important while often unmeasured confounder between the vaccination and infection. Hence, the design has been employed routinely to monitor…

二元结果下的个体风险量化AI 解读

Understanding treatment effect heterogeneity is crucial for reliable decision-making in treatment evaluation and selection. The conditional average treatment effect (CATE) is widely used to capture treatment effect heterogeneity induced by observed covariates and to design individualized treatment policies. However, it is an average metric within subpopulations, which prevents it from revealing individual risk, potentially leading to misleading results. This article fills…

随机对照试验中存在竞争性伴发事件的处理效应估计AI 解读

The analysis of randomized controlled trials is often complicated by intercurrent events (IEs) -- events that occur after treatment initiation and affect either the interpretation or existence of outcome measurements. Examples include treatment discontinuation or the use of additional medications. In two recent clinical trials for systemic lupus erythematosus with complications of IEs, we classify the IEs into two broad categories: effect-informative (e.g., treatment…

局部平均处理效应框架下聚类数据的两阶段最小二乘AI 解读

To estimate the causal effect of an endogenous treatment using clustered data, the canonical two-stage least squares (2sls) estimates a linear regression of the outcome on treatment status using an instrumental variable (IV) and conducts inference with cluster-robust standard errors. When both the treatment and the IV vary within clusters, an alternative two-stage least squares with fixed effects (2sfe) additionally includes cluster indicators in the regression, thereby…

双索引排列统计量的解耦与随机化AI 解读

This paper introduces a version of decoupling and randomization to establish concentration inequalities for double-indexed permutation statistics. The results yield, among other applications, a new combinatorial Hanson-Wright inequality and a new combinatorial Bennett inequality. Several illustrative examples from rank-based statistics, graph-based statistics, and causal inference are also provided.

含处理与协变量交互项的两阶段最小二乘及处理效应异质性AI 解读

Treatment effect heterogeneity with respect to covariates is common in instrumental variable (IV) analyses. An intuitive approach, which we call the interacted two-stage least squares (2sls), is to postulate a working linear model of the outcome on the treatment, covariates, and treatment-covariate interactions, and instrument it using the IV, covariates, and IV-covariate interactions. We clarify the causal interpretation of the interacted 2sls under the local average…

用于自助法的生成式建模AI 解读

Generative modeling builds on and substantially advances the classical idea of simulating synthetic data from observed samples. This paper shows that this principle is not only natural but also theoretically well-founded for bootstrap inference: it yields statistically valid confidence intervals that apply simultaneously to both regular and irregular estimators, including settings in which Efron's bootstrap fails. In this sense, the generative modeling-based bootstrap can be…

b 值：从敏感性分析视角组合无偏与有偏估计量AI 解读

In empirical research, when we have multiple estimators for the same parameter of interest, a central question arises: how do we combine unbiased but less precise estimators with biased but more precise ones to improve the inference? Under this setting, the point estimation problem has attracted considerable attention. In this paper, we focus on a less studied inference question: how can we conduct valid statistical inference in such settings with unknown bias? We propose a…

析因双重差分AI 解读

We formulate factorial difference-in-differences (FDID), a research design that extends canonical difference-in-differences (DID) to settings in which an event affects all units. In many panel data applications, researchers exploit cross-sectional variation in a baseline factor alongside temporal variation in the event, but the corresponding estimand is often implicit and the justification for applying the DID estimator remains unclear. We frame FDID as a factorial design…

观察性多因素研究中的因果推断平衡权重AI 解读

Many scientific questions in biomedical, environmental, and psychological research involve understanding the effects of multiple factors on outcomes. While factorial experiments are ideal for this purpose, randomized controlled treatment assignment is generally infeasible in many empirical studies. Therefore, investigators must rely on observational data, where drawing reliable causal inferences for multiple factors remains challenging. As the number of treatment…

统一时间序列实验中的回归式与设计式因果推断AI 解读

Time-series experiments, also called switchback experiments or N-of-1 trials, play increasingly important roles in modern applications in medical and industrial areas. Under the potential outcomes framework, recent research has studied time-series experiments from the design-based perspective, relying solely on the randomness in the design to drive the statistical inference. Focusing on simpler statistical methods, we examine the design-based properties of regression-based…

TERRA：用于纵向异质性处理效应估计的 Transformer 递归 R 学习器AI 解读

Accurately estimating heterogeneous treatment effects (HTE) in longitudinal settings is essential for personalized decision-making across healthcare, public policy, education, and digital marketing. However, time-varying interventions introduce many unique challenges, such as carryover effects, time-varying heterogeneity, and post-treatment bias, which are not addressed by standard HTE methods. To address these challenges, we introduce TERRA (Transformer-Enabled Recursive…

随机实验中实现无偏机器学习协变量调整的条件交叉拟合AI 解读

Randomized experiments are the gold standard for estimating the average treatment effect (ATE). While covariate adjustment can reduce the asymptotic variances of the unbiased Horvitz-Thompson estimators for the ATE, it suffers from finite-sample biases due to data reuse in both prediction and estimation. Traditional sample-splitting and cross-fitting methods can address the problem of data reuse and obtain unbiased estimators. However, they require that the data are…

利用辅助总体工具变量识别因果效应与多重稳健估计AI 解读

Estimating causal effects in a target population with unmeasured confounders is challenging, especially when instrumental variables (IVs) are unavailable. However, IVs from auxiliary populations with similar problems can help infer causal effects in the target population. While the homogeneous conditional average treatment effect assumption has been widely used for effect transportability, it has not been explored in IV-based data fusion. We include it as a basic approach,…