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用贝叶斯加性回归树评估观察数据中的治疗获益预测器AI 解读

A treatment benefit predictor (TBP) is an algorithm that maps a patient's characteristics to their putative benefit from a given treatment, which can be used to inform treatment decisions. However, a TBP must be evaluated in the target population before being adopted for patient care. When only observational data are available, evaluating TBPs requires standard causal identification assumptions, as treatment assignment in such settings is not random. We obtain the posterior…

函数形式灵活建模中协变量测量误差的校正方法：一项盲法、受控的中立比较模拟研究AI 解读

Covariate measurement error is pervasive in epidemiological research and distorts estimated exposure-outcome associations, yet correction methods have been studied almost exclusively under linear modelling assumptions. Their behaviour when the underlying association is non-linear and is itself estimated with flexible regression, remains poorly characterised. We report a blinded, multi-stage neutral comparison simulation study, conducted within the STRATOS initiative,…

函数形式灵活建模中协变量测量误差校正方法：一项盲法、受控的中立比较模拟研究设计AI 解读

This article describes the design of a neutral comparison study in the context of empirical studies where the interest is in learning the functional relationship between a continuous errorprone exposure variable and a binary outcome. The performance of combinations of measurement error correction methods and flexible regression modeling techniques was compared using a simulation study. The project involved four independent teams, one devoted to data generation and…

利用观测数据评价处理获益预测器：识别与混杂偏差AI 解读

A treatment benefit predictor (TBP) is a function that maps patient characteristics to an estimate of the treatment benefit for that patient. Such predictors support optimizing individualized treatment decisions, which are central to precision medicine. However, evaluating the predictive performance of a TBP is challenging, as this often must be conducted in a sample where treatment assignment is not random. After briefly reviewing several metrics for evaluating TBPs, we…

结局非可忽略缺失下离散数据的部分识别AI 解读

Nonignorable missing outcomes are common in real world datasets and often require strong parametric assumptions to achieve identification. These assumptions can be implausible or untestable, and so we may forgo them in favour of partially identified models that narrow the set of a priori possible values to an identification region. Here we propose a new nonparametric Bayes method that allows for the incorporation of multiple clinically relevant restrictions of the parameter…

结合参数与非参数模型估计观察性研究中的处理效应AI 解读

Performing causal inference in observational studies requires we assume confounding variables are correctly adjusted for. G-computation methods are often used in these scenarios, with several recent proposals using Bayesian versions of g-computation. In settings with few confounders, standard models can be employed, however as the number of confounders increase these models become less feasible as there are fewer observations available for each unique combination of…