Validity of tests for time-to-event endpoints in studies with the Pocock and Simon covariate-adaptive randomization
Pocock–Simon 协变量自适应随机化下生存终点检验的有效性
In the presence of prognostic covariates, inference about the treatment effect with time-to-event endpoints is mostly conducted via the stratified log-rank test or the score test based on the Cox proportional hazards model. In their ground-breaking work Ye and Shao (2020) have demonstrated theoretically that when the model is misspecified, the robust score test (Wei and Lin, 1989) as well as the unstratified log-rank test are conservative in trials with stratified…